PMID- 30639132
OWN - NLM
STAT- MEDLINE
DCOM- 20191218
LR  - 20200401
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Print)
IS  - 0002-9610 (Linking)
VI  - 217
IP  - 4
DP  - 2019 Apr
TI  - Association between postoperative opioid use and outpatient surgical adverse 
      events.
PG  - 605-612
LID - S0002-9610(18)31441-7 [pii]
LID - 10.1016/j.amjsurg.2018.12.068 [doi]
AB  - BACKGROUND: Opioid-related adverse drug events are common following inpatient 
      surgical procedures. Little is known about opioid prescribing after outpatient 
      surgical procedures and if opioid use is associated with short term risks of 
      outpatient surgical adverse events (AEs). METHODS: VA Corporate Data Warehouse 
      was used to identify opioid use within 48 h for FY2012-14 chart-reviewed cases 
      from a larger VA study of AEs in outpatient surgeries. We estimated a multilevel 
      logistic regression model to determine the effect of opioid exposure on risk of 
      AEs between 2 and 30 days postoperatively. RESULTS: Of the 1730 outpatient 
      surgical cases, 628 (36%) had postoperative opioid use and 12% had an AE. Opioid 
      use following outpatient surgery was not significantly associated with higher 
      surgical AE rates after controlling for relevant covariates (OR = 1.1 95% CI 
      0.79-1.54). Only procedure RVUs were associated with higher odds of postoperative 
      AEs. CONCLUSIONS: Postoperative opioid use following outpatient surgery is not a 
      significant driver of postoperative AEs.
CI  - Published by Elsevier Inc.
FAU - Dasinger, Elise A
AU  - Dasinger EA
AD  - VA Quality Scholars Program, Birmingham VA Medical Center, Birmingham, AL, United 
      States. Electronic address: Elise.Dasinger@va.gov.
FAU - Branch-Elliman, Westyn
AU  - Branch-Elliman W
AD  - Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston 
      Healthcare System, Boston, MA, United States; Department of Medicine, VA Boston 
      Healthcare System, Boston, MA, United States; Harvard Medical School, Boston, MA, 
      United States.
FAU - Pizer, Steven D
AU  - Pizer SD
AD  - Partnered Evidence-based Policy Resource Center (PEPReC), Department of Veterans 
      Affairs, Boston, MA, United States; Department of Health Law, Policy and 
      Management, Boston University School of Public Health, Boston, MA, United States.
FAU - Abdulkerim, Hassen
AU  - Abdulkerim H
AD  - Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston 
      Healthcare System, Boston, MA, United States.
FAU - Rosen, Amy K
AU  - Rosen AK
AD  - Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston 
      Healthcare System, Boston, MA, United States; Department of Surgery, Boston 
      University School of Medicine, Boston, MA, United States.
FAU - Charns, Martin P
AU  - Charns MP
AD  - Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston 
      Healthcare System, Boston, MA, United States; Department of Health Law, Policy 
      and Management, Boston University School of Public Health, Boston, MA, United 
      States.
FAU - Hawn, Mary T
AU  - Hawn MT
AD  - Palo Alto VA Medical Center, Palo Alto, CA, United States; Stanford University 
      School of Medicine, Stanford, CA, United States.
FAU - Itani, Kamal M F
AU  - Itani KMF
AD  - Harvard Medical School, Boston, MA, United States; Department of Surgery, Boston 
      University School of Medicine, Boston, MA, United States; Department of Surgery, 
      VA Boston Healthcare System, Boston, MA, United States.
FAU - Mull, Hillary J
AU  - Mull HJ
AD  - Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston 
      Healthcare System, Boston, MA, United States; Department of Surgery, Boston 
      University School of Medicine, Boston, MA, United States.
LA  - eng
GR  - K12 HL138049/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190104
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Aged
MH  - Ambulatory Surgical Procedures/*adverse effects
MH  - Analgesics, Opioid/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain, Postoperative/*drug therapy
MH  - Practice Patterns, Physicians'/statistics & numerical data
MH  - Retrospective Studies
MH  - Risk Factors
MH  - United States
MH  - United States Department of Veterans Affairs
PMC - PMC6664793
MID - NIHMS1041632
OTO - NOTNLM
OT  - Adverse events
OT  - Ambulatory surgery
OT  - Opioids
OT  - Patient safety
OT  - Quality improvement
OT  - Veterans
EDAT- 2019/01/15 06:00
MHDA- 2019/12/19 06:00
PMCR- 2020/04/01
CRDT- 2019/01/15 06:00
PHST- 2018/10/23 00:00 [received]
PHST- 2018/12/26 00:00 [revised]
PHST- 2018/12/31 00:00 [accepted]
PHST- 2019/01/15 06:00 [pubmed]
PHST- 2019/12/19 06:00 [medline]
PHST- 2019/01/15 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - S0002-9610(18)31441-7 [pii]
AID - 10.1016/j.amjsurg.2018.12.068 [doi]
PST - ppublish
SO  - Am J Surg. 2019 Apr;217(4):605-612. doi: 10.1016/j.amjsurg.2018.12.068. Epub 2019 
      Jan 4.