PMID- 30639923
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20200324
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 102
DP  - 2019 Apr
TI  - Neural systems underlying reward cue processing in early adolescence: The role of 
      puberty and pubertal hormones.
PG  - 281-291
LID - S0306-4530(18)30418-9 [pii]
LID - 10.1016/j.psyneuen.2018.12.016 [doi]
AB  - Affective neuroscience research suggests that maturational changes in reward 
      circuitry during adolescence present opportunities for new learning, but likely 
      also contribute to increases in vulnerability for psychiatric disorders such as 
      depression and substance abuse. Basic research in animal models and human 
      neuroimaging has made progress in understanding the normal development of reward 
      circuitry in adolescence, yet, few functional neuroimaging studies have examined 
      puberty-related influences on the functioning of this circuitry. The goal of this 
      study was to address this gap by examining the extent to which striatal 
      activation and cortico-striatal functional connectivity to cues predicting 
      upcoming rewards would be positively associated with pubertal status and levels 
      of pubertal hormones (dehydroepiandrosterone, testosterone, estradiol). 
      Participants included 79 adolescents (10-13 year olds; 47 girls) varying in 
      pubertal status who performed a novel reward cue processing task during fMRI. 
      Pubertal maturation was assessed using sex-specific standardized composite 
      measures based on Tanner staging (self-report and clinical assessment) and scores 
      from the Pubertal Development Scale. These composite measures were computed to 
      index overall pubertal maturation as well as maturation of the adrenal and 
      gonadal axes separately for boys and girls. Basal levels of circulating pubertal 
      hormones were measured using immunoassays from three samples collected weekly 
      upon awakening across a three-week period. Results indicated greater striatal 
      activation and functional connectivity between nucleus accumbens (NAcc) and 
      medial prefrontal cortex (mPFC) to reward cue (vs. no reward cue) on this task. 
      Also, girls with higher levels of estradiol showed reduced activation in left and 
      right caudate and greater NAcc-putamen connectivity. Girls with higher levels of 
      testosterone showed greater NAcc connectivity with the anterior cingulate cortex 
      and the insula. There were no significant associations in boys. Findings suggest 
      that patterns of activation and connectivity in cortico-striatal regions are 
      associated with reward cue processing, particularly in girls. Longitudinal 
      follow-up neuroimaging studies are needed to fully characterize puberty-specific 
      effects on the development of these neural regions and how such changes may 
      contribute to pathways of risk or resilience in adolescence.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Ladouceur, Cecile D
AU  - Ladouceur CD
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA. Electronic address: ladouceurcd@upmc.edu.
FAU - Kerestes, Rebecca
AU  - Kerestes R
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA.
FAU - Schlund, Michael W
AU  - Schlund MW
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA; Department of Psychology, Georgia State University, GA, USA.
FAU - Shirtcliff, Elizabeth A
AU  - Shirtcliff EA
AD  - Human Development Family Studies, Iowa State University, Ames, IA, USA.
FAU - Lee, Yoojin
AU  - Lee Y
AD  - Human Development Family Studies, Iowa State University, Ames, IA, USA.
FAU - Dahl, Ronald E
AU  - Dahl RE
AD  - Institute of Human Development, University of California, Berkeley, CA, USA.
LA  - eng
GR  - R01 MH099007/MH/NIMH NIH HHS/United States
GR  - UL1 TR001857/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181213
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Sesquiterpenes)
RN  - 0 (estafiatone)
RN  - 3XMK78S47O (Testosterone)
RN  - 459AG36T1B (Dehydroepiandrosterone)
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/physiology
MH  - Cerebral Cortex/metabolism/physiology
MH  - Child
MH  - Corpus Striatum/metabolism/physiology
MH  - Cues
MH  - Dehydroepiandrosterone/analysis
MH  - Female
MH  - Functional Neuroimaging/methods
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nucleus Accumbens/metabolism/physiology
MH  - Prefrontal Cortex/metabolism/physiology
MH  - Puberty/*physiology/*psychology
MH  - *Reward
MH  - Sesquiterpenes/analysis
MH  - Testosterone/analysis
PMC - PMC7085287
MID - NIHMS1560323
OTO - NOTNLM
OT  - Cortico-striatal regions
OT  - Pubertal hormones
OT  - Puberty
OT  - Reward cue processing
OT  - Sex differences
OT  - fMRI
EDAT- 2019/01/15 06:00
MHDA- 2020/03/18 06:00
PMCR- 2020/03/21
CRDT- 2019/01/15 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/12/11 00:00 [revised]
PHST- 2018/12/12 00:00 [accepted]
PHST- 2019/01/15 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2019/01/15 06:00 [entrez]
PHST- 2020/03/21 00:00 [pmc-release]
AID - S0306-4530(18)30418-9 [pii]
AID - 10.1016/j.psyneuen.2018.12.016 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2019 Apr;102:281-291. doi: 
      10.1016/j.psyneuen.2018.12.016. Epub 2018 Dec 13.