PMID- 30641036
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20200804
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1711
DP  - 2019 May 15
TI  - Effects of mild traumatic brain injury and post-traumatic stress disorder on 
      resting-state default mode network connectivity.
PG  - 77-82
LID - S0006-8993(19)30032-0 [pii]
LID - 10.1016/j.brainres.2019.01.015 [doi]
AB  - Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are 
      common outcomes for service members. Abnormal connectivity within neural networks 
      has been reported in the resting brain of mTBI and PTSD patients, respectively; 
      however, the potential role of PTSD in changes to neural networks following 
      injury has not been studied in detail. Using a data-driven approach, the present 
      analysis aimed to elucidate resting state functional connectivity in the default 
      mode network (DMN) in those with mTBI only and those with comorbid mTBI and PTSD. 
      A secondary analysis focused on distinct contributions by the anterior and 
      posterior DMN components. Group-level independent component analysis was used to 
      identify the DMN, and a dual-regression method was utilized to measure 
      connectivity within the overall network and its anterior (medial prefrontal 
      cortex) and posterior (posterior cingulate cortex) nodes. Connectivity within the 
      overall DMN was significantly higher for the mTBI only group (p = 0.001), as 
      compared to controls and mTBI + PTSD. For all subjects with mTBI, network 
      connectivity correlated inversely with PTSD checklist score (p < 0.05). 
      Additionally, distinct associations (p < 0.05) between medial prefrontal cortex 
      connectivity and PTSD symptoms and, separately, posterior cingulate cortex 
      connectivity and mTBI-related cognitive deficits were found. To our knowledge, 
      this is the first study to report a differential relationship between DMN 
      components and both post-traumatic symptoms and cognitive outcomes.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Santhanam, Priya
AU  - Santhanam P
AD  - Lovelace Biomedical Research, Albuquerque, NM, United States. Electronic address: 
      psanthanam@lrri.org.
FAU - Wilson, Steffanie H
AU  - Wilson SH
AD  - The Emmes Corporation, Rockville, MD, United States.
FAU - Oakes, Terrence R
AU  - Oakes TR
AD  - School of Medicine and Public Health, University of Wisconsin-Madison, Madison, 
      WI, United States.
FAU - Weaver, Lindell K
AU  - Weaver LK
AD  - Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, UT, United 
      States; Division of Hyperbaric Medicine, Intermountain LDS Hospital, Salt Lake 
      City, UT, United States; Department of Medicine, University of Utah, School of 
      Medicine, Salt Lake, UT, United States.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190111
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Adult
MH  - Brain/physiopathology
MH  - Brain Concussion/metabolism/*physiopathology
MH  - Brain Mapping/methods
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Military Personnel/psychology
MH  - Nerve Net/*physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Rest
MH  - Stress Disorders, Post-Traumatic/metabolism/*physiopathology
OTO - NOTNLM
OT  - Default mode network
OT  - Independent component analysis
OT  - Medial prefrontal cortex
OT  - Post-traumatic stress disorder
OT  - Posterior cingulate cortex
OT  - Traumatic brain injury
EDAT- 2019/01/15 06:00
MHDA- 2020/08/05 06:00
CRDT- 2019/01/15 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2019/01/09 00:00 [revised]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/01/15 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/01/15 06:00 [entrez]
AID - S0006-8993(19)30032-0 [pii]
AID - 10.1016/j.brainres.2019.01.015 [doi]
PST - ppublish
SO  - Brain Res. 2019 May 15;1711:77-82. doi: 10.1016/j.brainres.2019.01.015. Epub 2019 
      Jan 11.