PMID- 30641081
OWN - NLM
STAT- MEDLINE
DCOM- 20200429
LR  - 20200429
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 202
DP  - 2019 Apr 1
TI  - NMDA receptor in the hippocampus alters neurobehavioral phenotypes through 
      inflammatory cytokines in rats with sporadic Alzheimer-like disease.
PG  - 52-61
LID - S0031-9384(18)31098-9 [pii]
LID - 10.1016/j.physbeh.2019.01.005 [doi]
AB  - Many patients with sporadic Alzheimer's disease (AD) suffer from memory 
      impairment, anxiety- and depression. The systemic utility of N-Methyl-d-Aspartate 
      (NMDA) receptor antagonists has been shown to be potential therapeutic target for 
      memory loss in AD. However, there is no evidence that shows whether NMDA receptor 
      antagonists have the same effects when these blockers are directly used within 
      the brain regions including hippocampus. It might be an urgent to further explore 
      the therapeutic role of NMDA receptor antagonists in behavioral abnormalities 
      such as anxiety and depression in AD. The aim of this study was to determine 
      whether blockade of the hippocampal NMDA receptors could attenuate 
      neurobehavioral abnormalities in rats with sporadic AD. Twelve days after AD 
      induction by streptozotocin (STZ), animals received either vehicle or MK-801 
      (NMDA receptor antagonist) in the hippocampus for 10 days. Two or five days after 
      the last MK-801 treatment, spatial memory, anxiety- and depression-related 
      behaviors, and inflammatory cytokines (interleukin-(IL)-6, IL-1beta and tumor 
      necrosis factor (TNF)-alpha) were evaluated. Our findings indicated that STZ 
      treatment significantly elevated hippocampal inflammation, impaired spatial 
      memory, and increased anxiety- and depression-related symptoms in rats. 
      Interestingly, the hippocampal NMDA receptor blockade improved these 
      neurobehavioral phenotypes and decreased inflammatory cytokines in the 
      hippocampus of STZ-treated rats. Hippocampal NMDA receptors might be involved in 
      neurobehavioral abnormalities via inflammation in sporadic AD.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Amani, Mohammad
AU  - Amani M
AD  - Department of Physiology, School of Medicine, Ardabil University of Medical 
      Sciences, Ardabil, Iran; Department of Anatomy and Neurobiology, University of 
      California, Irvine, CA 92697, USA.
FAU - Zolghadrnasab, Maryam
AU  - Zolghadrnasab M
AD  - National Institute of Genetic Engineering and Biotechnology, Iran; Salari 
      Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, Karaj, Iran.
FAU - Salari, Ali-Akbar
AU  - Salari AA
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran; Salari Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, 
      Karaj, Iran. Electronic address: aa.salari@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20190111
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Alzheimer Disease/*metabolism
MH  - Animals
MH  - Anxiety/metabolism
MH  - Cytokines/*metabolism
MH  - Depression/metabolism
MH  - Disease Models, Animal
MH  - Dizocilpine Maleate/pharmacology
MH  - Hippocampus/*metabolism
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Maze Learning
MH  - Phenotype
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - Excitotoxicity
OT  - Glutamate
OT  - MK-801
OT  - Memory
EDAT- 2019/01/15 06:00
MHDA- 2020/04/30 06:00
CRDT- 2019/01/15 06:00
PHST- 2018/12/03 00:00 [received]
PHST- 2019/01/06 00:00 [revised]
PHST- 2019/01/09 00:00 [accepted]
PHST- 2019/01/15 06:00 [pubmed]
PHST- 2020/04/30 06:00 [medline]
PHST- 2019/01/15 06:00 [entrez]
AID - S0031-9384(18)31098-9 [pii]
AID - 10.1016/j.physbeh.2019.01.005 [doi]
PST - ppublish
SO  - Physiol Behav. 2019 Apr 1;202:52-61. doi: 10.1016/j.physbeh.2019.01.005. Epub 
      2019 Jan 11.