PMID- 30641621
OWN - NLM
STAT- MEDLINE
DCOM- 20190218
LR  - 20190219
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 36
IP  - 11
DP  - 2016 Nov
TI  - [Astragalus Granule Combined Auricular Point Sticking for Cough Variant Asthma in 
      Children].
PG  - 1308-1311
AB  - Objective To observe the clinical efficacy and effect of Astragalus Granule (AG) 
      , auricular point sticking combined with aerosol inhalation on the levels of 
      tumor necrosis factor-alpha (TNF- a), interleukin-4 (IL-4), interleukin-10 (IL-10), 
      eosinophil cell count (EOS), and immunoglobulin E (IgE) in cough variant asthma 
      (CVA) children. Methods Totally 150 CVA children patients were ran- domly 
      assigned to three group, the Western medicine group (WM) , the Chinese medicine 
      group (CM) , and the combined group, 50 in each group. All patients received 
      basic treatment of aerosol inhalation with Budesonide suspension and Terbutaline 
      Sulphate Solution. Patients in the WM group received basic treatment alone. Those 
      in the CM group additionally took AG. Those in the combined group additionally 
      took AG and received auricular point sticking. The therapeutic course for all was 
      8 weeks. Expression levels of TNF-alpha, IL-4, and IL-10 were detected in each group 
      using ELISA before and after treatment. Levels of EOS and IgE were detected using 
      hematology analyzer. Results Compared with before treatment in the same group, 
      the expression levels of TNF-alpha and IgE decreased in the WM group after treatment 
      (P < 0. 05) ; the expression levels of TNF-alpha, IL-4, EOS, and IgE decreased, but 
      the level of IL-10 increased in the CM group and the combined group after 
      treatment (P <0. 05). Compared with the WM group at the same time, the expression 
      level of IL-10 increased, and the level of IgE decreased in the CM group (P < 0. 
      05). The control rate, the markedly effective rate, and the total effective rate 
      were elevated (P < 0. 05), and the ineffective rate was lowered (P <0. 05) in the 
      CM group. In the combined group the expression levels of TNF-alpha, IL-4, EOS, and 
      IgE decreased, and the level of IL-10 increased after treatment (P <0. 05). The 
      cough alleviation time and the disappearance time were shortened in the combined 
      group after treatment (P <0. 05). The control rate, the markedly effective rate, 
      and the total effective rate were elevated (P <0. 05), and the ineffective rate 
      was lowered (P <0. 05) in the combined group after treatment. Compared with the 
      CM group at the same time point, the expression level of IL-10 increased (P < 0. 
      05), the levels of IgE and EOS were lowered (P <0. 05), the cough alleviation 
      time and the disappear- ance time were shortened (P <0. 05) , the control rate 
      and the total effective rate were elevated in the combined group after treatment 
      (P <0. 05). Conclusion AG, auricular point sticking combined with aerosol 
      inhalation could significantly reduce the levels of TNF-alpha, IL-4, EOS, and IgE, 
      and improve the level of IL-10 in CVA children patients, with significant 
      clinical effects.
FAU - Zhang, Li-Wen
AU  - Zhang LW
FAU - Reng, Ming-Xin
AU  - Reng MX
FAU - Xue, Guo-Chang
AU  - Xue GC
FAU - Shen, Lin-Na
AU  - Shen LN
FAU - Xia, Huan
AU  - Xia H
FAU - Song, Yue-Juan
AU  - Song YJ
FAU - Xia, Xue-Xia
AU  - Xia XX
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Asthma/complications/drug therapy
MH  - *Astragalus Plant
MH  - Child
MH  - *Cough/drug therapy/etiology
MH  - Drugs, Chinese Herbal
MH  - Eosinophils
MH  - Humans
MH  - Immunoglobulin E
MH  - *Plant Extracts/therapeutic use
EDAT- 2016/11/01 00:00
MHDA- 2016/11/01 00:01
CRDT- 2019/01/15 06:00
PHST- 2019/01/15 06:00 [entrez]
PHST- 2016/11/01 00:00 [pubmed]
PHST- 2016/11/01 00:01 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Nov;36(11):1308-1311.