PMID- 30641706
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20190513
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 1
DP  - 2019 Jan-Feb
TI  - Prevalence and associations of non-alcoholic fatty liver disease (NAFLD) in Sri 
      Lankan patients with type 2 diabetes: A single center study.
PG  - 246-250
LID - S1871-4021(18)30380-1 [pii]
LID - 10.1016/j.dsx.2018.09.002 [doi]
AB  - BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most common 
      causes for chronic liver disease in Asians. It occurs more commonly in patients 
      with type 2 diabetes mellitus (T2DM). However, data on prevalence and 
      associations of NAFLD among Sri Lankans with diabetes are lacking. The main aim 
      of this study is to investigate the prevalence and factors associated with NAFLD 
      in a cohort of diabetic patients. METHODS: Total of 233 patients with type 2 
      diabetes mellitus, followed up at a diabetes center in Southern Sri Lanka, were 
      recruited by convenience sampling method. Each of them underwent a detailed 
      medical history, physical examination, laboratory investigations and abdominal 
      ultrasonography(USS). The diagnosis of NAFLD was made according to the 
      established criteria using USS. RESULTS: The overall prevalence of NAFLD based on 
      USS was 62.6% with no significant gender difference. Compared to USS, elevation 
      in AST and ALT levels, based on NHANES III criteria, occurred only in 42% 
      (98/234). The patients with NAFLD (56.7 +/- 8.9) were significantly younger and had 
      higher BMI and waist circumference, and raised AST and ALT than those without 
      NAFLD. Binary logistic regression showed that the use of pioglitazone, higher 
      BMI, and waist circumference were independently and significantly associated with 
      NAFLD. CONCLUSIONS: NAFLD is common in Sri Lankan patients with T2DM and central 
      and global obesity are significant associations. Use of pioglitazone seemed to be 
      protective against the development of NAFLD. These findings underscore the need 
      for weight management as a preventive measure of NAFLD in T2DM patients.
CI  - Copyright (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Herath, Herath Mudiyanselage Meththananda
AU  - Herath HMM
AD  - Department of Medicine, Faculty of Medicine, PO Box 70, Galle, Sri Lanka. 
      Electronic address: herathtp@gmail.com.
FAU - Kodikara, Iroshani
AU  - Kodikara I
AD  - Department of Anatomy, Faculty of Medicine, PO Box 70, Galle, Sri Lanka. 
      Electronic address: iroshanikodikara@gmail.com.
FAU - Weerarathna, Thilak Priyantha
AU  - Weerarathna TP
AD  - Department of Medicine, Faculty of Medicine, PO Box 70, Galle, Sri Lanka. 
      Electronic address: thilak.priyantha@yahoo.com.
FAU - Liyanage, Gayani
AU  - Liyanage G
AD  - Department of Pharmacology, Faculty of Medicne, POBox 70, Galle, Sri Lanka. 
      Electronic address: gayanicl@yahoo.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180908
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*epidemiology/pathology
MH  - Prevalence
MH  - Prognosis
MH  - Sri Lanka/epidemiology
MH  - Young Adult
EDAT- 2019/01/16 06:00
MHDA- 2019/05/14 06:00
CRDT- 2019/01/16 06:00
PHST- 2018/08/16 00:00 [received]
PHST- 2018/09/07 00:00 [accepted]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
AID - S1871-4021(18)30380-1 [pii]
AID - 10.1016/j.dsx.2018.09.002 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Jan-Feb;13(1):246-250. doi: 10.1016/j.dsx.2018.09.002. 
      Epub 2018 Sep 8.