PMID- 30641751
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20190513
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 1
DP  - 2019 Jan-Feb
TI  - Increased insulin requirement may contribute to risk of obesity in children and 
      young people with Type 1 Diabetes Mellitus.
PG  - 492-495
LID - S1871-4021(18)30444-2 [pii]
LID - 10.1016/j.dsx.2018.11.005 [doi]
AB  - INTRODUCTION: Type 1 diabetes mellitus (T1DM) is an autoimmune disorder that 
      interferes with the function of the beta cells in the pancreas. Reports show that 
      the incidence of T1DM is increasing throughout England and Wales, along with the 
      Body Mass Index (BMI) of this patient group. The association between type 2 
      diabetes mellitus (T2DM) and obesity is recognised, but literature describing the 
      association between T1DM and high BMI is more limited. The aim of this paper is 
      to identify factors affecting BMI and the impact that this increasing trend has 
      on children and young people with T1DM. METHODS: Information was obtained from 
      the medical records of patients with T1DM at the local paediatric centre. BMI 
      standard deviation scores (SDS) were calculated and compared to other factors, 
      which include insulin requirement, HbA1c, pubertal status and age at diagnosis. 
      RESULTS: This study involved 102 patients (43 male and 59 female). The mean age 
      at diagnosis was 7.79 years (range from 0.16 to 16.91 years). Our results showed 
      a significant association between insulin requirement and BMI SDS (r = 0.23, 
      p = 0.02) and a significant association between insulin requirement and mean 
      HbA1c (r = 0.59, p=<0.01). A multivariable regression analysis of factors 
      affecting BMI SDS showed that insulin requirement was an independent factor 
      affecting BMI SDS. CONCLUSION: There were significant associations between 
      increased insulin requirement, high BMI SDS and poorer glycaemic control. Further 
      research is required to fully understand the risk factors that may contribute to 
      obesity in T1DM.
CI  - Copyright (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Apperley, Louise J
AU  - Apperley LJ
AD  - Department of Paediatrics, Southport and Ormskirk NHS Trust, Wigan Road, 
      Ormskirk, L39 2AZ, UK.
FAU - Ng, Sze May
AU  - Ng SM
AD  - Department of Paediatrics, Southport and Ormskirk NHS Trust, Wigan Road, 
      Ormskirk, L39 2AZ, UK; Department of Women's and Children's Health, Institute of 
      Translational Medicine, University of Liverpool, Crown Street, L8 7SS, Liverpool, 
      UK. Electronic address: may.ng@nhs.net.
LA  - eng
PT  - Journal Article
DEP - 20181103
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/analysis
MH  - Body Mass Index
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*complications/drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/*metabolism
MH  - Infant
MH  - Insulin/administration & dosage/*metabolism
MH  - *Insulin Resistance
MH  - Male
MH  - Pediatric Obesity/*etiology/pathology
MH  - Prognosis
OTO - NOTNLM
OT  - Glycemic control
OT  - Insulin requirement
OT  - Obesity
OT  - Type 1 Diabetes Mellitus
EDAT- 2019/01/16 06:00
MHDA- 2019/05/14 06:00
CRDT- 2019/01/16 06:00
PHST- 2018/09/17 00:00 [received]
PHST- 2018/11/02 00:00 [accepted]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
AID - S1871-4021(18)30444-2 [pii]
AID - 10.1016/j.dsx.2018.11.005 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Jan-Feb;13(1):492-495. doi: 10.1016/j.dsx.2018.11.005. 
      Epub 2018 Nov 3.