PMID- 30641767
OWN - NLM
STAT- MEDLINE
DCOM- 20190426
LR  - 20201019
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 1
DP  - 2019 Jan-Feb
TI  - Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients 
      with diabetic nephropathy.
PG  - 564-568
LID - S1871-4021(18)30464-8 [pii]
LID - 10.1016/j.dsx.2018.11.022 [doi]
AB  - AIMS: Diabetic nephropathy (DN) is a serious microvascular complication of a 
      longstanding hyperglycemia. This study aims to evaluate whether urinary 
      neutrophil gelatinase-associated lipocalin (NGAL) and urinary Interleukin-18 
      possess a better diagnostic value than albumin creatinine ratio in assessing the 
      severity of nephropathy in patients with type 2 diabetes mellitus (T2DM). 
      MATERIAL & METHODS: Ninety participants diagnosed with T2DM were recruited and 
      they were divided into three study groups according to their albumin/creatinine 
      ratio (ACR): (Normoalbuminuria group, Microalbuminuria group, and 
      Macroalbuminuria group). A matching of Ninety healthy subjects were included as 
      controls. Blood and urine samples were collected to measure various markers of 
      glycemic control and kidney function. RESULTS: IL-18 levels were not changed 
      significantly between all study groups (P > 0.05), despite a significant positive 
      correlation between IL-18 and urinary albumin levels. NGAL levels were 
      significantly increased in Microalbuminuria group and Macroalbuminuria group as 
      compared to the control and Normoalbuminuria groups. NGAL was also positively 
      correlated with urinary albumin and ACR, but negatively correlated with the age 
      and body mass index. Receiver Operating Characteristic curves revealed that for 
      early detection of DN, the best cutoff values to discriminate DN and diabetic 
      without nephropathy groups were > 21.4 ng/ml for NGAL (94.67 sensitivity, 26.67% 
      specificity), </=0.34 pg/mL for IL-18 (72% sensitivity, 53.33% specificity), and 
      >29.8 mg/g for ACR (80% sensitivity, 100% specificity). CONCLUSION: We conclude 
      that the urinary ACR is a more accurate individual biomarker of DN when compared 
      to both NGAL and IL-18.
CI  - Copyright (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Sueud, Taqwaa
AU  - Sueud T
AD  - Faculty of Medicine, University of Kufa, Al-Najaf, Iraq.
FAU - Hadi, Najah R
AU  - Hadi NR
AD  - Faculty of Medicine, University of Kufa, Al-Najaf, Iraq.
FAU - Abdulameer, Raed
AU  - Abdulameer R
AD  - Faculty of Medicine, University of Kufa, Al-Najaf, Iraq.
FAU - Jamil, Dina A
AU  - Jamil DA
AD  - School of Medicine, University of Tasmania, Hobart, TAS, 7000, Australia.
FAU - Al-Aubaidy, Hayder A
AU  - Al-Aubaidy HA
AD  - School of Medicine, University of Tasmania, Hobart, TAS, 7000, Australia; School 
      of Life Sciences, La Trobe University, Bundoora, VIC, 3086, Australia. Electronic 
      address: h.alaubaidy@latrobe.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20181110
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - AYI8EX34EU (Creatinine)
RN  - ZIF514RVZR (Serum Albumin, Human)
SB  - IM
MH  - Adult
MH  - Biomarkers/urine
MH  - Creatinine/*urine
MH  - Diabetes Mellitus, Type 2/diagnosis/*urine
MH  - Diabetic Nephropathies/diagnosis/*urine
MH  - Female
MH  - Humans
MH  - Interleukin-18/*urine
MH  - Lipocalin-2/*urine
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin, Human/*urine
OTO - NOTNLM
OT  - Albumin creatinine ration
OT  - Diabetic nephropathy
OT  - Interlukin-18
OT  - Neutrophil gelatinase-associated lipocalin
OT  - Type 2 diabetes
EDAT- 2019/01/16 06:00
MHDA- 2019/04/27 06:00
CRDT- 2019/01/16 06:00
PHST- 2018/10/02 00:00 [received]
PHST- 2018/11/02 00:00 [accepted]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/04/27 06:00 [medline]
AID - S1871-4021(18)30464-8 [pii]
AID - 10.1016/j.dsx.2018.11.022 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Jan-Feb;13(1):564-568. doi: 10.1016/j.dsx.2018.11.022. 
      Epub 2018 Nov 10.