PMID- 30641796
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 1
DP  - 2019 Jan-Feb
TI  - The morphofunctional features of platelets against the background of metabolic 
      syndrome in patients with generalized marginal periodontitis.
PG  - 730-733
LID - S1871-4021(18)30506-X [pii]
LID - 10.1016/j.dsx.2018.11.057 [doi]
AB  - According to modern ideas, disorders in the system of hemostasis in 
      cardiovascular diseases are mainly due to an increase in the functional activity 
      of platelets, namely their increased ability to adhere and aggregate. Aim of the 
      research was to evaluate morphofunctional platelets of patients with marginal 
      periodontitis. Material and methods of the study involved 129 men aged 28-50 
      years (mean age 42.97 +/- 1.31 years) suffering from a MS with generalized 
      periodontitis of mild and moderate degree. We also formed a control group of 90 
      practically healthy men (mean age 42.17 +/- 1.34 years). Exclusion criteria are 
      symptomatic AH, unstable angina, myocardial infarction or stroke in history, 
      severe chronic heart failure, severe liver and kidney disease, diabetes, complete 
      secondary adentia. Patients were performed the dental examination with 
      determination of community periodontal index of treatment needs (CPITN), X-ray 
      examination, physical examination with determination of anthropometric data, as 
      well as clinical, the definition of MS laboratory criteria, insulin resistance 
      indices, 24-h blood pressure monitoring. Platelet morphology was studied using 
      scanning electron [17 clauser] microscopy (PhilipsPSEM 550 h) on samples prepared 
      by a special method. The results of the study of platelet morphology in patients 
      with MS and control group revealed a non-uniform pattern. The number of platelets 
      in both groups being almost equal (249,6 +/- 8,3small ha, Cyrillic109/l and 256,8 +/- 8,7small ha, Cyrillic109/l 
      respectively). Conclusion: The presented data provide strong evidence for changes 
      in the morphofunctional state of peripheral blood platelets in patients with 
      generalized marginal periodontitis of mild and moderate degree against the 
      background of metabolic syndrome.
CI  - Copyright (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Vasil'ev, Yu L
AU  - Vasil'ev YL
AD  - I.M. Sechenov First Moscow State Medical University of the Ministry of Health of 
      the Russian Federation (Sechenov University), Department of Operative Surgery and 
      Topographic Anatomy, Moscow, Russia. Electronic address: dr.vasiliev@gmail.com.
FAU - Kytko, O V
AU  - Kytko OV
AD  - I.M. Sechenov First Moscow State Medical University of the Ministry of Health of 
      the Russian Federation (Sechenov University), Department of Operative Surgery and 
      Topographic Anatomy, Moscow, Russia.
FAU - Smetneva, N S
AU  - Smetneva NS
AD  - A.I. Evdokimov Moscow State University of Medicine and Dentistry, Department of 
      Faculty Therapy and Occupational Diseases, Moscow, Russia.
FAU - Goloborodova, I V
AU  - Goloborodova IV
AD  - A.I. Evdokimov Moscow State University of Medicine and Dentistry, Department of 
      Faculty Therapy and Occupational Diseases, Moscow, Russia.
FAU - Nelipa, M V
AU  - Nelipa MV
AD  - I.M. Sechenov First Moscow State Medical University of the Ministry of Health of 
      the Russian Federation (Sechenov University), Department of Operative Surgery and 
      Topographic Anatomy, Moscow, Russia.
LA  - eng
PT  - Journal Article
DEP - 20181203
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
SB  - IM
MH  - Adult
MH  - Blood Platelets/*pathology/physiology
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood/complications/physiopathology
MH  - Middle Aged
MH  - Periodontitis/*blood/complications
OTO - NOTNLM
OT  - Aggregation
OT  - Dentistry
OT  - Diagnostics
OT  - Hemostasis
OT  - Metabolic syndrome
OT  - Periodontitis
OT  - Platelets
EDAT- 2019/01/16 06:00
MHDA- 2019/05/02 06:00
CRDT- 2019/01/16 06:00
PHST- 2018/10/24 00:00 [received]
PHST- 2018/11/30 00:00 [accepted]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
AID - S1871-4021(18)30506-X [pii]
AID - 10.1016/j.dsx.2018.11.057 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Jan-Feb;13(1):730-733. doi: 10.1016/j.dsx.2018.11.057. 
      Epub 2018 Dec 3.