PMID- 30642220
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20210208
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 160
IP  - 6
DP  - 2019 Jun
TI  - p16 Influence on Laryngeal Squamous Cell Carcinoma Relapse and Survival.
PG  - 1042-1047
LID - 10.1177/0194599818821910 [doi]
AB  - OBJECTIVE: (1) To identify p16 protein in laryngeal squamous cell carcinoma 
      (LSCC) specimens and to correlate it with the presence of human papillomavirus 
      (HPV) found in these specimens from a previous study. (2) To analyze p16 impact 
      on 10-year overall and disease-free survival. STUDY DESIGN: Retrospective case 
      series with oncologic database chart review. SETTING: Academic tertiary care 
      hospital. SUBJECTS: A total of 123 samples of LSCC (taken from the glottis only) 
      from patients treated with primary surgical resection between 1977 and 2005. 
      METHODS: p16 protein expression was analyzed through immunohistochemistry and 
      compared with the presence of HPV established in our previous studies. Results 
      were compared with histologic, clinicopathologic, and survival parameters, with a 
      10-year follow-up. RESULTS: Of the samples, 39.02% were positive for p16, but 
      only 11.38% were positive for both p16 and HPV. The p16+ cohort showed a 
      significant improvement in disease-free survival ( P = .0022); statistical 
      significance was not achieved for overall survival. p16+ cases had fewer relapses 
      over time, with no relapses after a 2-year follow-up. Age at the time of 
      diagnosis and tobacco consumption were the only epidemiologic factors that 
      influenced overall survival. CONCLUSION: The expression of p16 protein was a 
      beneficial prognostic factor for disease-free survival among patients with LSCC 
      of the glottis, with no relapses after a 2-year follow-up.
FAU - Sanchez Barrueco, Alvaro
AU  - Sanchez Barrueco A
AD  - 1 ENT and Cervicofacial Surgery Department, Hospital Universitario Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Gonzalez Galan, Fernando
AU  - Gonzalez Galan F
AD  - 1 ENT and Cervicofacial Surgery Department, Hospital Universitario Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Villacampa Auba, Jose Miguel
AU  - Villacampa Auba JM
AD  - 1 ENT and Cervicofacial Surgery Department, Hospital Universitario Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Diaz Tapia, Gonzalo
AU  - Diaz Tapia G
AD  - 1 ENT and Cervicofacial Surgery Department, Hospital Universitario Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Fernandez Hernandez, Sofia
AU  - Fernandez Hernandez S
AD  - 2 Pathology Department, Haugesund Sjukehus Helse Fonna, Haugesund, Norway.
FAU - Martin-Arriscado Arroba, Cristina
AU  - Martin-Arriscado Arroba C
AD  - 3 Spanish Clinical Research Network, Hospital Universitario 12 de Octubre, 
      Madrid, Spain.
FAU - Cenjor Espanol, Carlos
AU  - Cenjor Espanol C
AD  - 1 ENT and Cervicofacial Surgery Department, Hospital Universitario Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Almodovar Alvarez, Carlos
AU  - Almodovar Alvarez C
AD  - 4 ENT and Cervicofacial Surgery Department. Hospital Universitario 12 de Octubre, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190115
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/blood/*mortality/virology
MH  - Cyclin-Dependent Kinase Inhibitor p16/*blood
MH  - Disease-Free Survival
MH  - Female
MH  - *Glottis
MH  - Humans
MH  - Laryngeal Neoplasms/blood/*mortality/virology
MH  - Male
MH  - Middle Aged
MH  - *Papillomaviridae
MH  - Papillomavirus Infections/blood/complications/*mortality
MH  - Retrospective Studies
MH  - Survival Rate
OTO - NOTNLM
OT  - disease-free survival
OT  - larynx
OT  - p16
OT  - relapse
OT  - squamous cell carcinoma
EDAT- 2019/01/16 06:00
MHDA- 2020/01/14 06:00
CRDT- 2019/01/16 06:00
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
AID - 10.1177/0194599818821910 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2019 Jun;160(6):1042-1047. doi: 
      10.1177/0194599818821910. Epub 2019 Jan 15.