PMID- 30642655
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 1532-8503 (Electronic)
IS  - 1051-2276 (Linking)
VI  - 29
IP  - 4
DP  - 2019 Jul
TI  - Low-Fiber Intake Is Associated With High Production of Intraperitoneal 
      Inflammation Biomarkers.
PG  - 322-327
LID - S1051-2276(18)30253-X [pii]
LID - 10.1053/j.jrn.2018.10.013 [doi]
AB  - OBJECTIVE: Fiber intake influences disturbances in the gastrointestinal tract and 
      is associated with systemic inflammation in the general population. Systemic and 
      intraperitoneal inflammation play an important role in defining outcomes in 
      peritoneal dialysis (PD), but the relationship between dietary fiber intake and 
      inflammatory biomarkers has not yet been reported in the population on PD. The 
      objective of the present study is to analyze whether or not fiber intake in 
      patients on PD is associated with serum and intraperitoneal levels of 
      inflammatory biomarkers. DESIGN AND METHODS: Adult and clinically stable PD 
      patients were included in this observational and cross-sectional study. Fiber 
      intake was assessed by means of a dietary survey and calculated using the DietPro 
      program 5.6i. The population was divided into two groups according to the median 
      fiber intake. We investigated interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, 
      monocyte chemoattractant protein-1 (MCP-1), B-cell-activating factor, and 
      plasminogen-activator inhibitor-1 in both serum and peritoneal fluid. The latter 
      was determined after a dwell time of 4 hours. RESULTS: Fifty-two patients (42% 
      men; aged 53 +/- 14 years, 36% diabetics) were evaluated. Low intake of dietary 
      fiber was found in 90% of patients, with a median of 12.2 g per day (3.4-33.3). 
      The group with the highest fiber intake presented lower intraperitoneal levels of 
      IL-6, IL-8, and MCP-1. In contrast, only MCP-1 was lower in the serum of those 
      who consumed more fiber. All the associations remained significant after 
      adjustment for confounders with plasminogen-activator inhibitor-1 included. 
      CONCLUSIONS: Patients on PD frequently present inadequate dietary fiber intake, 
      which appears to have an association with the inflammatory response, particularly 
      in the intraperitoneal component. Further prospective studies, evaluating whether 
      or not a dietetic intervention with a focus on fiber intake affects these 
      biomarkers and clinical outcomes, are essential to determine causality and 
      clinical relevance.
CI  - Copyright (c) 2018 National Kidney Foundation, Inc. Published by Elsevier Inc. All 
      rights reserved.
FAU - Erthal Leinig, Cyntia
AU  - Erthal Leinig C
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil. Electronic address: cyntia.leinig@pucpr.br.
FAU - Pecoits-Filho, Roberto
AU  - Pecoits-Filho R
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil.
FAU - Kunii, Luiz
AU  - Kunii L
AD  - State University of Londrina, Londrina, Brazil; Pontifical Catholic University of 
      Parana (PUCPR), Londrina, Brazil.
FAU - Claro, Ligia Maria
AU  - Claro LM
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil.
FAU - Merlin, Julio
AU  - Merlin J
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil.
FAU - Almeida, Naiane Rodrigues de
AU  - Almeida NR
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil.
FAU - Carvalho, Camila Rodrigues de S
AU  - Carvalho CRS
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil.
FAU - Moraes, Thyago Proenca de
AU  - Moraes TP
AD  - School of Medicine, Pontifical Catholic University of Parana (PUCPR), Curitiba, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20190111
PL  - United States
TA  - J Ren Nutr
JT  - Journal of renal nutrition : the official journal of the Council on Renal 
      Nutrition of the National Kidney Foundation
JID - 9112938
RN  - 0 (Biomarkers)
RN  - 0 (Dietary Fiber)
SB  - IM
MH  - Biomarkers/blood/metabolism
MH  - Cross-Sectional Studies
MH  - Diet
MH  - Dietary Fiber/*metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/blood/*metabolism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Peritoneal Cavity/*physiopathology
EDAT- 2019/01/16 06:00
MHDA- 2020/08/20 06:00
CRDT- 2019/01/16 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/09/20 00:00 [revised]
PHST- 2018/10/20 00:00 [accepted]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
AID - S1051-2276(18)30253-X [pii]
AID - 10.1053/j.jrn.2018.10.013 [doi]
PST - ppublish
SO  - J Ren Nutr. 2019 Jul;29(4):322-327. doi: 10.1053/j.jrn.2018.10.013. Epub 2019 Jan 
      11.