PMID- 30642944
OWN - NLM
STAT- MEDLINE
DCOM- 20191217
LR  - 20240409
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 216
IP  - 2
DP  - 2019 Feb 4
TI  - LUBAC determines chemotherapy resistance in squamous cell lung cancer.
PG  - 450-465
LID - 10.1084/jem.20180742 [doi]
AB  - Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common 
      lung cancer subtypes. Molecular targeted treatments have improved LADC patient 
      survival but are largely ineffective in LSCC. The tumor suppressor FBW7 is 
      commonly mutated or down-regulated in human LSCC, and oncogenic KRasG12D 
      activation combined with Fbxw7 inactivation in mice (KF model) caused both LSCC 
      and LADC. Lineage-tracing experiments showed that CC10(+), but not basal, cells 
      are the cells of origin of LSCC in KF mice. KF LSCC tumors recapitulated human 
      LSCC resistance to cisplatin-based chemotherapy, and we identified LUBAC-mediated 
      NF-kappaB signaling as a determinant of chemotherapy resistance in human and mouse. 
      Inhibition of NF-kappaB activation using TAK1 or LUBAC inhibitors resensitized LSCC 
      tumors to cisplatin, suggesting a future avenue for LSCC patient treatment.
CI  - (c) 2019 Ruiz et al.
FAU - Ruiz, E Josue
AU  - Ruiz EJ
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
FAU - Diefenbacher, Markus E
AU  - Diefenbacher ME
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
FAU - Nelson, Jessica K
AU  - Nelson JK
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
FAU - Sancho, Rocio
AU  - Sancho R
AUID- ORCID: 0000-0002-4894-5391
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
FAU - Pucci, Fabio
AU  - Pucci F
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
FAU - Chakraborty, Atanu
AU  - Chakraborty A
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
FAU - Moreno, Paula
AU  - Moreno P
AD  - Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Spain.
AD  - Unidad de Cirugia Toracica y Trasplante Pulmonar, Hospital Universitario Reina 
      Sofia, Cordoba, Spain.
FAU - Annibaldi, Alessandro
AU  - Annibaldi A
AD  - Breast Cancer Now, Toby Robins Research Centre, Institute of Cancer Research, 
      London, UK.
FAU - Liccardi, Gianmaria
AU  - Liccardi G
AD  - Breast Cancer Now, Toby Robins Research Centre, Institute of Cancer Research, 
      London, UK.
FAU - Encheva, Vesela
AU  - Encheva V
AD  - Proteomics, The Francis Crick Institute, London, UK.
FAU - Mitter, Richard
AU  - Mitter R
AUID- ORCID: 0000-0002-1279-3760
AD  - Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
FAU - Rosenfeldt, Mathias
AU  - Rosenfeldt M
AD  - Comprehensive Cancer Center Mainfranken, University of Wurzburg, Wurzburg, 
      Germany.
FAU - Snijders, Ambrosius P
AU  - Snijders AP
AD  - Proteomics, The Francis Crick Institute, London, UK.
FAU - Meier, Pascal
AU  - Meier P
AD  - Breast Cancer Now, Toby Robins Research Centre, Institute of Cancer Research, 
      London, UK.
FAU - Calzado, Marco A
AU  - Calzado MA
AUID- ORCID: 0000-0002-5338-535X
AD  - Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Spain.
AD  - Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de 
      Cordoba, Cordoba, Spain.
FAU - Behrens, Axel
AU  - Behrens A
AUID- ORCID: 0000-0002-1557-1143
AD  - Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK 
      axel.behrens@crick.ac.uk.
AD  - Faculty of Life Sciences and Medicine, King's College London, London, UK.
LA  - eng
GR  - FC001039/ARC_/Arthritis Research UK/United Kingdom
GR  - FC001039/MRC_/Medical Research Council/United Kingdom
GR  - 12-0149/AICR_/Worldwide Cancer Research/United Kingdom
GR  - FC001039/WT_/Wellcome Trust/United Kingdom
GR  - FC001039/CRUK_/Cancer Research UK/United Kingdom
GR  - 281661/ERC_/European Research Council/International
GR  - MR/M019217/1/MRC_/Medical Research Council/United Kingdom
GR  - 14-1328/AICR_/Worldwide Cancer Research/United Kingdom
GR  - MR/S000011/1/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 24399/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190114
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (KRAS protein, human)
RN  - 0 (Multienzyme Complexes)
RN  - EC 3.6.5.2 (Hras protein, mouse)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adenocarcinoma of Lung/drug therapy/enzymology/genetics/pathology
MH  - Animals
MH  - Carcinoma, Squamous Cell/drug therapy/*enzymology/genetics/pathology
MH  - Cisplatin/pharmacology
MH  - *Drug Resistance, Neoplasm
MH  - Humans
MH  - Lung Neoplasms/drug therapy/*enzymology/genetics/pathology
MH  - Mice
MH  - Multienzyme Complexes/genetics/*metabolism
MH  - Proto-Oncogene Proteins p21(ras)/genetics/metabolism
MH  - *Ubiquitination
PMC - PMC6363428
EDAT- 2019/01/16 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/02/04
CRDT- 2019/01/16 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/12/18 00:00 [accepted]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/02/04 00:00 [pmc-release]
AID - jem.20180742 [pii]
AID - 20180742 [pii]
AID - 10.1084/jem.20180742 [doi]
PST - ppublish
SO  - J Exp Med. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742. Epub 2019 Jan 
      14.