PMID- 30643105
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20200225
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 81
IP  - 2
DP  - 2019 Feb 28
TI  - Relationship between motor function and ultrasonic vocalizations induced by 
      maternal separation in rat pups.
PG  - 287-293
LID - 10.1292/jvms.18-0604 [doi]
AB  - When rat pups are isolated from their mothers, they emit ultrasonic vocalizations 
      (USVs). Although previous studies have reported that USVs are related to anxiety, 
      others have reported that they are related to simple, nonemotional factors, such 
      as physiological reactions to coldness. In this study, we examined the influence 
      of three maternal separations on rat pups. The number of USVs during 5 min of USV 
      test under maternal separation, latency in the righting reflex as motor function, 
      and body temperature were recorded twice (the first and second tests) before and 
      after the pups were put in various environments for 10 min. The environments were 
      no maternal separation (Control: CON), maternal separation with littermates 
      (LMS), and single maternal separation with a heater (SMS). In the second test, 
      the SMS pups had fewer USVs, a lower body temperature, and a more rapid righting 
      reflex than the CON and LMS pups. In addition, there was no strong correlation 
      between USVs and righting reflex. As a result, pups undergoing 10 min of SMS 
      while being kept warm by the heater showed rapid righting reflex. Thus, by a 
      single maternal separation, the number of USVs decreased but the decrease was 
      unrelated to decrease in motor function.
FAU - Isobe, Anna
AU  - Isobe A
AD  - Lab of Animal Behavior and Environmental Science, Graduate School of Agriculture, 
      Meiji University, 1-1-1, Higashimita, Tama, Kawasaki, Kanagawa 214-8571, Japan.
FAU - Kawaguchi, Maiko
AU  - Kawaguchi M
AD  - Lab of Animal Behavior and Environmental Science, Graduate School of Agriculture, 
      Meiji University, 1-1-1, Higashimita, Tama, Kawasaki, Kanagawa 214-8571, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190115
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology/psychology
MH  - Female
MH  - Male
MH  - *Maternal Deprivation
MH  - Motor Activity/*physiology
MH  - Rats/*physiology/psychology
MH  - Rats, Wistar/physiology/psychology
MH  - Ultrasonics
MH  - Vocalization, Animal/*physiology
PMC - PMC6395214
OTO - NOTNLM
OT  - anxiety-like behavior
OT  - maternal separation
OT  - motor function
OT  - rat pup
OT  - ultrasonic vocalization
EDAT- 2019/01/16 06:00
MHDA- 2019/03/19 06:00
PMCR- 2019/02/01
CRDT- 2019/01/16 06:00
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 18-0604 [pii]
AID - 10.1292/jvms.18-0604 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2019 Feb 28;81(2):287-293. doi: 10.1292/jvms.18-0604. Epub 2019 
      Jan 15.