PMID- 30643981
OWN - NLM
STAT- MEDLINE
DCOM- 20200618
LR  - 20240410
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 54
IP  - 3
DP  - 2019 Mar
TI  - Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging 
      science.
PG  - 218-225
LID - 10.1007/s00535-018-01542-w [doi]
AB  - Alcohol and high-fat diet are two major risk factors responsible for metabolic 
      diseases, which are manifested as steatohepatitis and liver cancer in the liver, 
      and chronic pancreatitis and pancreatic adenocarcinoma (PDAC) in the pancreas. 
      These metabolic diseases are becoming increasingly prevalent around the globe, 
      and more importantly, their two major etiologies commonly coexist to precipitate 
      the disease processes. To highlight the importance of these metabolic diseases, 
      Japanese Society of Gastroenterology (JSGE) and National Institute on Alcoholism 
      and Alcohol Abuse of National Institute of Health cosponsored the JSGE's 7th 
      International Forum jointly held with the 12th International Symposium on ALPD 
      and Cirrhosis. Toward the main theme of "Frontiers in ASH, NASH, NBNC-HCC and 
      PDAC", this platform showcased presentations by 12 invited international and 
      Japanese speakers on brain-gut-liver interactions, emerging mechanisms of ASH and 
      NASH, metabolic reprogramming, and new therapeutic targets for cirrhosis, HCC, 
      and PDAC. This editorial discusses the most recent data on global statistics on 
      how alcohol and obesity impact health and longevity as a prelude to a brief 
      summary of the symposium presentations and discussions, primarily focusing on the 
      first two session themes.
FAU - Brar, Gurmehr
AU  - Brar G
AD  - Southern California Research Center for ALPD and Cirrhosis, Department of 
      Pathology, Keck School of Medicine, University of Southern California, 1333 San 
      Pablo Street, MMR-402, Los Angeles, CA, 90033, USA.
FAU - Tsukamoto, Hidekazu
AU  - Tsukamoto H
AUID- ORCID: 0000-0002-6833-2998
AD  - Southern California Research Center for ALPD and Cirrhosis, Department of 
      Pathology, Keck School of Medicine, University of Southern California, 1333 San 
      Pablo Street, MMR-402, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.
AD  - Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA. 
      htsukamo@med.usc.edu.
LA  - eng
GR  - P50 AA011999/AA/NIAAA NIH HHS/United States
GR  - R13 AA020691/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20190114
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Alcoholism/complications/epidemiology
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Fatty Liver, Alcoholic/diagnosis/*epidemiology/prevention & control
MH  - Female
MH  - Global Burden of Disease/*statistics & numerical data/trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/diagnosis/*epidemiology/prevention & control
MH  - Obesity/complications/epidemiology
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - Young Adult
PMC - PMC6394716
OTO - NOTNLM
OT  - Alcoholic steatohepatitis
OT  - High-fat diet
OT  - Non-alcoholic fatty liver disease
OT  - Non-alcoholic steatohepatitis
OT  - Risk factors
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/01/16 06:00
MHDA- 2020/06/19 06:00
PMCR- 2019/01/14
CRDT- 2019/01/16 06:00
PHST- 2018/11/13 00:00 [received]
PHST- 2018/12/19 00:00 [accepted]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2020/06/19 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/14 00:00 [pmc-release]
AID - 10.1007/s00535-018-01542-w [pii]
AID - 1542 [pii]
AID - 10.1007/s00535-018-01542-w [doi]
PST - ppublish
SO  - J Gastroenterol. 2019 Mar;54(3):218-225. doi: 10.1007/s00535-018-01542-w. Epub 
      2019 Jan 14.