PMID- 30644179
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20210109
IS  - 2162-3279 (Electronic)
VI  - 9
IP  - 2
DP  - 2019 Feb
TI  - Altered functional connectivity in binge eating disorder and bulimia nervosa: A 
      resting-state fMRI study.
PG  - e01207
LID - 10.1002/brb3.1207 [doi]
LID - e01207
AB  - INTRODUCTION: The etiology of bulimic-type eating (BTE) disorders such as binge 
      eating disorder (BED) and bulimia nervosa (BN) is still largely unknown. Brain 
      networks subserving the processing of rewards, emotions, and cognitive control 
      seem to play a crucial role in the development and maintenance of eating 
      disorders. Therefore, further investigations into the neurobiological 
      underpinnings are needed to discern abnormal connectivity patterns in BTE 
      disorders. METHODS: The present study aimed to investigate functional as well as 
      seed-based connectivity within well-defined brain networks. Twenty-seven 
      individuals with BED, 29 individuals with BN, 28 overweight, and 30 normal-weight 
      control participants matched by age, gender, and education underwent 
      resting-state functional magnetic resonance imaging. Functional connectivity was 
      assessed by spatial group independent component analysis and a seed-based 
      correlation approach by examining the default mode network (DMN), salience 
      network (SN), and executive network (EN). RESULTS: Group comparisons revealed 
      that BTE disorder patients exhibit aberrant functional connectivity in the dorsal 
      anterior cingulate cortex (dACC) within the SN, as well as in the medial 
      prefrontal cortex within the DMN. Furthermore, BED and BN groups differed from 
      each other in functional connectivity within each network. Seed-based 
      correlational analysis revealed stronger synchronous dACC-retrosplenial cortex 
      activity in the BN group. CONCLUSION: Our findings demonstrate abnormalities in 
      brain networks involved in salience attribution, self-referential processing, and 
      cognitive control in bulimic-type eating disorders. Together with our observation 
      of functional connectivity differences between BED and BN, this study offers a 
      differentiated account of both similarities and differences regarding brain 
      connectivity in BED and BN.
CI  - (c) 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
FAU - Stopyra, Marion A
AU  - Stopyra MA
AUID- ORCID: 0000-0003-2046-6476
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
AD  - Psychological Institute, Heidelberg University, Heidelberg, Germany.
FAU - Simon, Joe J
AU  - Simon JJ
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
AD  - Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, 
      Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
FAU - Skunde, Mandy
AU  - Skunde M
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
FAU - Walther, Stephan
AU  - Walther S
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
AD  - Department of General Adult Psychiatry, Centre for Psychosocial Medicine, 
      University Hospital Heidelberg, Heidelberg, Heidelberg, Germany.
FAU - Bendszus, Martin
AU  - Bendszus M
AD  - Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Herzog, Wolfgang
AU  - Herzog W
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
FAU - Friederich, Hans-Christoph
AU  - Friederich HC
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
AD  - Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, 
      Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190115
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
MH  - Adult
MH  - Binge-Eating Disorder/physiopathology/psychology
MH  - Bulimia Nervosa/physiopathology/psychology
MH  - Connectome/*methods
MH  - Emotions
MH  - Female
MH  - Gyrus Cinguli/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Prefrontal Cortex/*physiopathology
MH  - Reward
MH  - Self-Control
PMC - PMC6379643
OTO - NOTNLM
OT  - binge eating disorder
OT  - bulimia nervosa
OT  - functional connectivity
OT  - resting-state fMRI
EDAT- 2019/01/16 06:00
MHDA- 2019/08/14 06:00
PMCR- 2019/01/15
CRDT- 2019/01/16 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2018/11/22 00:00 [revised]
PHST- 2018/12/11 00:00 [accepted]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/15 00:00 [pmc-release]
AID - BRB31207 [pii]
AID - 10.1002/brb3.1207 [doi]
PST - ppublish
SO  - Brain Behav. 2019 Feb;9(2):e01207. doi: 10.1002/brb3.1207. Epub 2019 Jan 15.