PMID- 30644305
OWN - NLM
STAT- MEDLINE
DCOM- 20190614
LR  - 20190614
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 32
IP  - 6 Suppl. 1
DP  - 2018 Nov-Dec
TI  - Targeting VEGF-A in cartilage repair and regeneration: state of the art and 
      perspectives.
PG  - 217-224
AB  - Osteoarthritis (OA) is the most common joint disorders in western populations, 
      and is characterized by a progressive degradation of articular cartilage (AC) 
      leading to loss of joint function. Methods to cure, delay or prevent the onset of 
      OA and/or improve AC repair strategies have high clinical and socioeconomic 
      impact. Possible innovative strategies envisioned for early OA treatments or 
      cartilage repair include the implantation/injection of mesenchymal progenitors 
      (MPs)-based constructs or cell-free bioactive scaffolds/hydrogel coupled with the 
      controlled recruitment and instruction of resident MPs or AC. However, these 
      tissue engineering-based strategies still suffer from unreliable outcomes with 
      poor fibro-cartilaginous repair and blood vessel invasion. In such conditions 
      Vascular Endothelial Growth Factor (VEGF) family has been shown to play a key 
      role in controlling AC catabolism on one hand and angiogenesis on the other as a 
      crucial step for endochondral ossification of MPs, ultimately leading to 
      progressive breakdown of the neo-formed matrix. This review aims to provide a 
      summary of relevant relationships between impaired angiogenesis, OA and cartilage 
      regeneration highlighting how VEGF might play a paramount role in the 
      pathophysiology of cartilage aging or degeneration as well as in cartilage 
      repair.
FAU - Vadala, G
AU  - Vadala G
AD  - Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of 
      Rome, Rome, Italy.
FAU - Russo, F
AU  - Russo F
AD  - Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of 
      Rome, Rome, Italy.
FAU - Musumeci, M
AU  - Musumeci M
AD  - Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of 
      Rome, Rome, Italy.
FAU - Giacalone, A
AU  - Giacalone A
AD  - Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of 
      Rome, Rome, Italy.
FAU - Papalia, R
AU  - Papalia R
AD  - Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of 
      Rome, Rome, Italy.
FAU - Denaro, V
AU  - Denaro V
AD  - Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of 
      Rome, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Cartilage, Articular/*physiopathology
MH  - Humans
MH  - Osteoarthritis/*physiopathology
MH  - Regeneration
MH  - Tissue Engineering
MH  - Vascular Endothelial Growth Factor A/*physiology
EDAT- 2019/01/16 06:00
MHDA- 2019/06/15 06:00
CRDT- 2019/01/16 06:00
PHST- 2019/01/16 06:00 [entrez]
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/06/15 06:00 [medline]
AID - 32 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6 Suppl. 1):217-224.