PMID- 30645708
OWN - NLM
STAT- MEDLINE
DCOM- 20190802
LR  - 20200225
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 42
IP  - 2
DP  - 2019 Apr
TI  - Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in 
      Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-kappaB Signaling.
PG  - 440-448
LID - 10.1007/s10753-018-00953-4 [doi]
AB  - This study investigated the protective effect and underlying mechanism of action 
      of umbelliferone (Umb) against lipopolysaccharide (LPS)-induced acute lung injury 
      (ALI). An intragastric Umb injection prior to the administration of LPS 
      dramatically decreased the wet/dry lung weight ratio, attenuated inflammatory 
      cell infiltration in lung tissue, and reduced the LPS-induced production of 
      inflammatory cytokines, including monocyte chemotactic protein-1(MCP-1), 
      interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta, in 
      broncheoalveolar lavage fluid (BALF). In addition, Umb resulted in significant 
      anti-oxidative effects as shown by decreased myeloperoxidase (MPO) and 
      malondialdehyde (MDA) activity and increased superoxide dismutase (SOD) activity 
      compared with the LPS group. Finally, the inhibitory effects of Umb on the 
      expression of toll-like receptor 4 (TLR4)/myeloid differentiation protein 88 
      (MyD88)/nuclear factor-kappaB (NF-kappaB) signaling pathway proteins were also measured. 
      Our results clearly indicated that Umb exerted significant protective effects on 
      LPS-induced ALI by inhibiting the activation of the TLR4/MyD88/NF-kappaB pathway.
FAU - Wang, Dongqiu
AU  - Wang D
AD  - Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 
      274031, China.
FAU - Wang, Xia
AU  - Wang X
AD  - Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 
      274031, China.
FAU - Tong, Wen
AU  - Tong W
AD  - Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 
      274031, China.
FAU - Cui, Yuhong
AU  - Cui Y
AD  - Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 
      274031, China.
FAU - Li, Xiuxian
AU  - Li X
AD  - Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 
      274031, China.
FAU - Sun, Haiyun
AU  - Sun H
AD  - Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 
      274031, China. haiysun66@126.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Protective Agents)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Umbelliferones)
MH  - Acute Lung Injury/*pathology
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology
MH  - Cytokines/biosynthesis/drug effects
MH  - Inflammation/chemically induced/*drug therapy
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - NF-kappa B/metabolism
MH  - Protective Agents/pharmacology
MH  - Signal Transduction/*drug effects
MH  - Toll-Like Receptor 4/metabolism
MH  - Umbelliferones/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - TLR4/MyD88/NF-kappaB signaling
OT  - acute lung injury
OT  - umbelliferone
EDAT- 2019/01/16 06:00
MHDA- 2019/08/03 06:00
CRDT- 2019/01/16 06:00
PHST- 2019/01/16 06:00 [pubmed]
PHST- 2019/08/03 06:00 [medline]
PHST- 2019/01/16 06:00 [entrez]
AID - 10.1007/s10753-018-00953-4 [pii]
AID - 10.1007/s10753-018-00953-4 [doi]
PST - ppublish
SO  - Inflammation. 2019 Apr;42(2):440-448. doi: 10.1007/s10753-018-00953-4.