PMID- 30646969
OWN - NLM
STAT- MEDLINE
DCOM- 20200102
LR  - 20231011
IS  - 1555-3884 (Electronic)
IS  - 1052-2166 (Print)
IS  - 1052-2166 (Linking)
VI  - 19
IP  - 2
DP  - 2019 Apr 18
TI  - Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology.
PG  - 69-87
LID - 10.3727/105221619X15469715711907 [doi]
AB  - The term blood-bile barrier (BBlB) refers to the physical structure within a 
      hepatic lobule that compartmentalizes and hence segregates sinusoidal blood from 
      canalicular bile. Thus, this barrier provides physiological protection in the 
      liver, shielding the hepatocytes from bile toxicity and restricting the mixing of 
      blood and bile. BBlB is primarily composed of tight junctions; however, adherens 
      junction, desmosomes, gap junctions, and hepatocyte bile transporters also 
      contribute to the barrier function of the BBlB. Recent findings also suggest that 
      disruption of BBlB is associated with major hepatic diseases characterized by 
      cholestasis and aberrations in BBlB thus may be a hallmark of many chronic liver 
      diseases. Several molecular signaling pathways have now been shown to play a role 
      in regulating the structure and function and eventually contribute to regulation 
      of the BBlB function within the liver. In this review, we will discuss the 
      structure and function of the BBlB, summarize the methods to assess the integrity 
      and function of BBlB, discuss the role of BBlB in liver pathophysiology, and 
      finally, discuss the mechanisms of BBlB regulation. Collectively, this review 
      will demonstrate the significance of the BBlB in both liver homeostasis and 
      hepatic dysfunction.
FAU - Pradhan-Sundd, Tirthadipa
AU  - Pradhan-Sundd T
AD  - Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA, USA.
FAU - Monga, Satdarshan Pal
AU  - Monga SP
AD  - Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA, USA.
LA  - eng
GR  - R01 CA204586/CA/NCI NIH HHS/United States
GR  - R01 DK062277/DK/NIDDK NIH HHS/United States
GR  - R01 DK100287/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190115
PL  - United States
TA  - Gene Expr
JT  - Gene expression
JID - 9200651
SB  - IM
MH  - Animals
MH  - Bile Canaliculi/*anatomy & histology/*blood supply
MH  - Blood Vessels/anatomy & histology
MH  - Hepatocytes/physiology
MH  - Humans
MH  - Intercellular Junctions
MH  - Liver/*anatomy & histology/*blood supply/physiopathology
MH  - Liver Diseases/blood/pathology/physiopathology
PMC - PMC6466181
EDAT- 2019/01/17 06:00
MHDA- 2020/01/03 06:00
PMCR- 2019/04/18
CRDT- 2019/01/17 06:00
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2020/01/03 06:00 [medline]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2019/04/18 00:00 [pmc-release]
AID - GE397 [pii]
AID - 10.3727/105221619X15469715711907 [doi]
PST - ppublish
SO  - Gene Expr. 2019 Apr 18;19(2):69-87. doi: 10.3727/105221619X15469715711907. Epub 
      2019 Jan 15.