PMID- 30647622
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240406
IS  - 2090-5920 (Electronic)
IS  - 1687-157X (Print)
IS  - 1687-157X (Linking)
VI  - 14
IP  - 2
DP  - 2016 Dec
TI  - Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus 
      in Egyptians.
PG  - 247-251
LID - 10.1016/j.jgeb.2016.10.004 [doi]
AB  - In this work we studied association of common variants in transcription factor 
      7-like 2 (TCF7L2) and cyclin-dependent kinase 5 regulatory subunit-associated 
      protein 1-like 1 (CDKAL1) genes with type 2 diabetes mellitus (T2DM) in 
      Egyptians. SUBJECTS AND METHODS: This is a case-control study; 180 T2DM patients 
      and 210 control subjects were genotyped for TCF7L2 rs7903146 and rs12255372 and 
      CDKAL1 rs7756992 single nucleotide polymorphisms (SNPs) by TaqMan method on real 
      time polymerase chain reaction system (real time-PCR). RESULTS: TCF7L2 rs12255372 
      and rs7903146 associated with T2DM (p = 0.0001 and 0.003; respectively). The 
      rs12255372 variant T allele associated with 2-fold increased risk for T2DM and TT 
      genotype carriers were at 3.58-folds higher risk to develop T2DM than wild 
      genotype (GG) carriers. Meanwhile, rs7903146 variant T allele associated with 
      1.6-fold increased risk for T2DM and TT genotype carriers were at 2.3-folds 
      higher risk than wild genotype (CC) carriers. Both TCF7L2 SNPs significantly 
      associated with T2DM under additive and dominant models and after adjustment for 
      other covariates. On the other hand, CDKAL1 rs7756992 showed no significant 
      association with T2DM under any genetic model. Both TCF7L2 SNPs were in strong LD 
      (P = 0.02; D' = 0.85). Taking common TCF7L2 rs12255372/rs7903146 GC haplotype as 
      reference, multivariate analysis confirmed the association of rs12255372 T 
      allele-containing haplotypes (TC and TT) with T2DM. Haplotype TC associated with 
      6.32 times-higher risk for T2DM (95%CI = 0.55-76.17, Pc = 0.04) followed by 
      haplotype TT which associated with 3.88 times-higher risk for the disease 
      (95%CI = 1.09-13.76, Pc = 0.03). CONCLUSION: TCF7L2 rs12255372 and rs7903146 
      common variants associate with T2DM risk in Egyptians.
FAU - El-Lebedy, Dalia
AU  - El-Lebedy D
AD  - Department of Clinical and Chemical Pathology, Medical Research Division, 
      National Research Centre, Cairo, Egypt.
FAU - Ashmawy, Ingy
AU  - Ashmawy I
AD  - Department of Clinical and Chemical Pathology, Medical Research Division, 
      National Research Centre, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20161105
PL  - Netherlands
TA  - J Genet Eng Biotechnol
JT  - Journal, genetic engineering & biotechnology
JID - 101317150
PMC - PMC6299909
OTO - NOTNLM
OT  - CDKAL1
OT  - Polymorphism
OT  - TCF7L2
OT  - Type 2 diabetes mellitus
EDAT- 2016/12/01 00:00
MHDA- 2016/12/01 00:01
PMCR- 2016/11/05
CRDT- 2019/01/17 06:00
PHST- 2016/07/17 00:00 [received]
PHST- 2016/09/21 00:00 [revised]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2016/12/01 00:00 [pubmed]
PHST- 2016/12/01 00:01 [medline]
PHST- 2016/11/05 00:00 [pmc-release]
AID - S1687-157X(16)30052-X [pii]
AID - 10.1016/j.jgeb.2016.10.004 [doi]
PST - ppublish
SO  - J Genet Eng Biotechnol. 2016 Dec;14(2):247-251. doi: 10.1016/j.jgeb.2016.10.004. 
      Epub 2016 Nov 5.