PMID- 30647760
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200928
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2018
DP  - 2018
TI  - Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke 
      through a Network Pharmacology Approach.
PG  - 2582843
LID - 10.1155/2018/2582843 [doi]
LID - 2582843
AB  - Ischemic stroke is accompanied by high mortality and morbidity rates. At present, 
      there is no effective clinical treatment. Alternatively, traditional Chinese 
      medicine has been widely used in China and Japan for the treatment of ischemic 
      stroke. Baicalin is a flavonoid extracted from Scutellaria baicalensis that has 
      been shown to be effective against ischemic stroke; however, its mechanism has 
      not been fully elucidated. Based on network pharmacology, we explored the 
      potential mechanism of baicalin on a system level. After obtaining baicalin 
      structural information from the PubChem database, an approach combined with 
      literature mining and PharmMapper prediction was used to uncover baicalin 
      targets. Ischemic stroke-related targets were gathered with the help of DrugBank, 
      Online Mendelian Inheritance in Man (OMIM), Genetic Association Database (GAD), 
      and Therapeutic Target Database (TTD). Protein-protein interaction (PPI) networks 
      were constructed through the Cytoscape plugin BisoGenet and analyzed by 
      topological methods. Gene ontology (GO) and Kyoto Encyclopedia of Genes and 
      Genomes (KEGG) pathway enrichment were carried out via the Database for 
      Annotation, Visualization, and Integrated Discovery (DAVID) server. We obtained a 
      total of 386 potential targets and 5 signaling pathways, including 
      mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/protein 
      kinase B (AKT), hypoxia-inducible factor-1 (HIF-1), nuclear factor kappa B 
      (NF-kappaB), and forkhead box (FOXO) signaling pathways. GO analysis showed that 
      these targets were associated with antiapoptosis, antioxidative stress, 
      anti-inflammation, and other physiopathological processes that are involved in 
      anti-ischemic stroke effects. In summary, the mechanism of baicalin against 
      ischemic stroke involved multiple targets and signaling pathways. Our study 
      provides a network pharmacology framework for future research on traditional 
      Chinese medicine.
FAU - Xu, Tian
AU  - Xu T
AUID- ORCID: 0000-0003-0907-0067
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Ma, Chongyang
AU  - Ma C
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Fan, Shuning
AU  - Fan S
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Deng, Nan
AU  - Deng N
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Lian, Yajun
AU  - Lian Y
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Tan, Ling
AU  - Tan L
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Du, Weizhe
AU  - Du W
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Zhang, Shuang
AU  - Zhang S
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Liu, Shuling
AU  - Liu S
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Ren, Beida
AU  - Ren B
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Li, Zhenhan
AU  - Li Z
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Wang, Qingguo
AU  - Wang Q
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Wang, Xueqian
AU  - Wang X
AUID- ORCID: 0000-0001-9138-1491
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Cheng, Fafeng
AU  - Cheng F
AUID- ORCID: 0000-0002-3409-1196
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
LA  - eng
PT  - Journal Article
DEP - 20181217
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavonoids)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (NF-kappa B)
RN  - 347Q89U4M5 (baicalin)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
EIN - Evid Based Complement Alternat Med. 2019 Apr 3;2019:4520704. PMID: 31073316
MH  - Anti-Inflammatory Agents/chemistry/pharmacology/therapeutic use
MH  - Antioxidants/chemistry/pharmacology/therapeutic use
MH  - Apoptosis/drug effects
MH  - Brain Ischemia/drug therapy/*metabolism
MH  - Databases, Genetic
MH  - Drugs, Chinese Herbal/chemistry/*pharmacology/therapeutic use
MH  - Flavonoids/chemistry/*pharmacology/therapeutic use
MH  - Forkhead Transcription Factors/metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/metabolism
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Molecular Docking Simulation
MH  - Molecular Structure
MH  - NF-kappa B/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phytotherapy
MH  - Protein Interaction Maps
MH  - Scutellaria baicalensis/*chemistry
MH  - Signal Transduction
MH  - Stroke/drug therapy/*metabolism
PMC - PMC6311886
EDAT- 2019/01/17 06:00
MHDA- 2019/01/17 06:01
PMCR- 2018/12/17
CRDT- 2019/01/17 06:00
PHST- 2018/10/11 00:00 [received]
PHST- 2018/11/09 00:00 [revised]
PHST- 2018/12/06 00:00 [accepted]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2019/01/17 06:01 [medline]
PHST- 2018/12/17 00:00 [pmc-release]
AID - 10.1155/2018/2582843 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2018 Dec 17;2018:2582843. doi: 
      10.1155/2018/2582843. eCollection 2018.