PMID- 30647803
OWN - NLM
STAT- MEDLINE
DCOM- 20190604
LR  - 20220331
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2018
DP  - 2018
TI  - Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung 
      Cancer.
PG  - 9845123
LID - 10.1155/2018/9845123 [doi]
LID - 9845123
AB  - BACKGROUND: The correlation between tumor markers (TM) and TNM stage of 
      non-small-cell lung cancer (NSCLC) has not been widely reported. METHODS: TM 
      levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases 
      of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma (LSCC), 
      and 103 cases of benign chest disease (BCD) were analyzed before treatment. 
      RESULTS: By Kendall's tau-b correlation analysis, CEA, CA125, CA15-3, CA19-9, 
      CA72-4, CYFRA21-1, and SCC-Ag were correlated with T stage of LAC (r = 0.235, p < 
      0.05; r = 0.298, p < 0.05; r = 0.254, p < 0.05; r = 0.063, p < 0.05; r = 0.080, p 
      < 0.05; r = 0.268, p < 0.05; and r = 0.080, p < 0.05). CEA, CA125, CA15-3, 
      CA19-9, CA72-4, and CYFRA21-1 were correlated with N stage of LAC (r = 0.356, p < 
      0.05; r = 0.415, p < 0.05; r = 0.340, p < 0.05; r = 0.117, p < 0.05; r = 0.175, p 
      < 0.05; and r = 0.351, p < 0.05). CEA, CA125, CA15-3, CA19-9, CA72-4, and 
      CYFRA21-1 were correlated with M stage of LAC (r = 0.365, p < 0.05; r = 0.353, p 
      < 0.05; r = 0.293, p < 0.05; r = 0.135, p < 0.05; r = 0.169, p < 0.05; and r = 
      0.312, p < 0.05). CA125, CYFRA21-1, and SCC-Ag were correlated with T stage of 
      LSCC (r = 0.202, p < 0.05; r = 0.233, p < 0.05; and r = 0.099, p < 0.05). CA125 
      and CYFRA21-1 were correlated with N stage of LSCC (r = 0.178, p < 0.05 and r = 
      0.284, p < 0.05). CA125, CA15-3, and CYFRA21-1 were correlated with M stage of 
      LSCC (r = 0.214, p < 0.05; r = 0.152, p < 0.05; and r = 0.213, p < 0.05). 
      Combining hazard ratio, AUC, sensitivity, specificity, NPV, and PPV, it was 
      concluded that CEA and CYFRA21-1were the most related TM of LAC. SCC-Ag and 
      CYFRA21-1 were the most related TM of LSCC. CONCLUSIONS: CEA combined with 
      CYFRA21-1 contributed to auxiliary diagnosis of LAC. CYFRA21-1 combined with 
      SCC-Ag contributed to auxiliary diagnosis of LSCC. CEA, CA125, CA15-3, CA19-9, 
      CA72-4, and CYFRA21-1 were correlated with primary tissue and metastasis of LAC. 
      CA125 and CYFRA21-1 were correlated with primary tissue and metastasis of LSCC.
FAU - Chen, Zhong-Qing
AU  - Chen ZQ
AD  - Department of Clinical Laboratory, Guangxi Medical University Affiliated Tumor 
      Hospital, Nanning, 530021 Guangxi Province, China.
FAU - Huang, Ling-Sha
AU  - Huang LS
AUID- ORCID: 0000-0002-5372-7815
AD  - Department of Clinical Laboratory, Guangxi Medical University Affiliated Tumor 
      Hospital, Nanning, 530021 Guangxi Province, China.
FAU - Zhu, Bo
AU  - Zhu B
AUID- ORCID: 0000-0003-1189-644X
AD  - Department of Clinical Laboratory, Guangxi Medical University Affiliated Tumor 
      Hospital, Nanning, 530021 Guangxi Province, China.
LA  - eng
PT  - Journal Article
DEP - 20181211
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Tumor-Associated, Carbohydrate)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CA-125 Antigen)
RN  - 0 (CA-72-4 antigen)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Keratin-19)
RN  - 0 (MUC1 protein, human)
RN  - 0 (MUC16 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mucin-1)
RN  - 0 (antigen CYFRA21.1)
RN  - 0 (carbohydrate antigen 199, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Neoplasm/metabolism
MH  - Antigens, Tumor-Associated, Carbohydrate/metabolism
MH  - Biomarkers, Tumor/*metabolism
MH  - CA-125 Antigen/metabolism
MH  - Carcinoembryonic Antigen/metabolism
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis/metabolism
MH  - Female
MH  - Humans
MH  - Keratin-19/metabolism
MH  - Lung Neoplasms/*diagnosis/metabolism
MH  - Male
MH  - Membrane Proteins/metabolism
MH  - Middle Aged
MH  - Mucin-1/metabolism
MH  - Neoplasm Staging
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC6311751
EDAT- 2019/01/17 06:00
MHDA- 2019/06/05 06:00
PMCR- 2018/12/11
CRDT- 2019/01/17 06:00
PHST- 2018/07/17 00:00 [received]
PHST- 2018/08/12 00:00 [revised]
PHST- 2018/09/09 00:00 [accepted]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2019/06/05 06:00 [medline]
PHST- 2018/12/11 00:00 [pmc-release]
AID - 10.1155/2018/9845123 [doi]
PST - epublish
SO  - Dis Markers. 2018 Dec 11;2018:9845123. doi: 10.1155/2018/9845123. eCollection 
      2018.