PMID- 30648193
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20200401
IS  - 1432-0428 (Electronic)
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 62
IP  - 4
DP  - 2019 Apr
TI  - Maternal glucose levels during pregnancy and childhood adiposity in the 
      Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study.
PG  - 598-610
LID - 10.1007/s00125-018-4809-6 [doi]
AB  - AIMS/HYPOTHESIS: Maternal type 2 diabetes during pregnancy and gestational 
      diabetes are associated with childhood adiposity; however, associations of lower 
      maternal glucose levels during pregnancy with childhood adiposity, independent of 
      maternal BMI, remain less clear. The objective was to examine associations of 
      maternal glucose levels during pregnancy with childhood adiposity in the 
      Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. METHODS: The HAPO 
      Study was an observational epidemiological international multi-ethnic 
      investigation that established strong associations of glucose levels during 
      pregnancy with multiple adverse perinatal outcomes. The HAPO Follow-up Study 
      (HAPO FUS) included 4832 children from ten HAPO centres whose mothers had a 75 g 
      OGTT at ~28 weeks gestation 10-14 years earlier, with glucose values blinded to 
      participants and clinical caregivers. The primary outcome was child adiposity, 
      including: (1) being overweight/obese according to sex- and age-specific cut-offs 
      based on the International Obesity Task Force (IOTF) criteria; (2) IOTF-defined 
      obesity only; and (3) measurements >85th percentile for sum of skinfolds, waist 
      circumference and per cent body fat. Primary predictors were maternal OGTT and 
      HbA(1c) values during pregnancy. RESULTS: Fully adjusted models that included 
      maternal BMI at pregnancy OGTT indicated positive associations between maternal 
      glucose predictors and child adiposity outcomes. For one SD difference in 
      pregnancy glucose and HbA(1c) measures, ORs for each child adiposity outcome were 
      in the range of 1.05-1.16 for maternal fasting glucose, 1.11-1.19 for 1 h 
      glucose, 1.09-1.21 for 2 h glucose and 1.12-1.21 for HbA(1c). Associations were 
      significant, except for associations of maternal fasting glucose with offspring 
      being overweight/obese or having waist circumference >85th percentile. Linearity 
      was confirmed in all adjusted models. Exploratory sex-specific analyses indicated 
      generally consistent associations for boys and girls. CONCLUSIONS/INTERPRETATION: 
      Exposure to higher levels of glucose in utero is independently associated with 
      childhood adiposity, including being overweight/obese, obesity, skinfold 
      thickness, per cent body fat and waist circumference. Glucose levels less than 
      those diagnostic of diabetes are associated with greater childhood adiposity; 
      this may have implications for long-term metabolic health.
FAU - Lowe, William L Jr
AU  - Lowe WL Jr
AD  - Department of Medicine, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, 60611, USA.
FAU - Lowe, Lynn P
AU  - Lowe LP
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Kuang, Alan
AU  - Kuang A
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Catalano, Patrick M
AU  - Catalano PM
AD  - MetroHealth Medical Center, Cleveland, OH, USA.
AD  - Nutrition Obesity Research Center, School of Medicine, Case Western Reserve 
      University, Cleveland, OH, USA.
FAU - Nodzenski, Michael
AU  - Nodzenski M
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Talbot, Octavious
AU  - Talbot O
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Tam, Wing-Hung
AU  - Tam WH
AD  - Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, 
      Hong Kong, China.
AD  - Prince of Wales Hospital, Hong Kong, China.
FAU - Sacks, David A
AU  - Sacks DA
AD  - Kaiser Permanente Southern California, Pasadena, CA, USA.
FAU - McCance, David
AU  - McCance D
AD  - Royal Victoria Hospital, Belfast, UK.
FAU - Linder, Barbara
AU  - Linder B
AD  - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), 
      National Institutes of Health, Bethesda, MD, USA.
FAU - Lebenthal, Yael
AU  - Lebenthal Y
AD  - Schneider Children's Medical Center of Israel, Petah-Tiqva, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Lawrence, Jean M
AU  - Lawrence JM
AD  - Kaiser Permanente Southern California, Pasadena, CA, USA.
FAU - Lashley, Michele
AU  - Lashley M
AD  - School of Clinical Medicine and Research, Queen Elizabeth Hospital, University of 
      the West Indies, St Michael, Barbados.
FAU - Josefson, Jami L
AU  - Josefson JL
AD  - Department of Pediatrics, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
AD  - Ann and Robert H Lurie Children's Hospital, Chicago, IL, USA.
FAU - Hamilton, Jill
AU  - Hamilton J
AD  - The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
FAU - Deerochanawong, Chaicharn
AU  - Deerochanawong C
AD  - Rajavithi Hospital, Bangkok, Thailand.
FAU - Clayton, Peter
AU  - Clayton P
AD  - Royal Manchester Children's Hospital, Royal Manchester University Hospitals, NHS 
      Foundation Trust, Manchester, UK.
AD  - Manchester Academic Health Sciences Centre, School of Medical Sciences, Faculty 
      of Biology, Medicine & Health, University of Manchester, Manchester, UK.
FAU - Brickman, Wendy J
AU  - Brickman WJ
AD  - Department of Pediatrics, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
AD  - Ann and Robert H Lurie Children's Hospital, Chicago, IL, USA.
FAU - Dyer, Alan R
AU  - Dyer AR
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Scholtens, Denise M
AU  - Scholtens DM
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Metzger, Boyd E
AU  - Metzger BE
AD  - Department of Medicine, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, 60611, USA. bem@northwestern.edu.
CN  - HAPO Follow-up Study Cooperative Research Group
LA  - eng
GR  - U01 DK094830/DK/NIDDK NIH HHS/United States
GR  - UL1 TR001422/TR/NCATS NIH HHS/United States
GR  - UL1 TR002548/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
DEP - 20190115
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Blood Glucose)
SB  - IM
MH  - *Adiposity
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - Body Mass Index
MH  - Child
MH  - Diabetes, Gestational/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hyperglycemia/*blood
MH  - Male
MH  - Maternal Age
MH  - Overweight
MH  - Pediatric Obesity/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Pregnancy Outcome
MH  - Pregnancy in Diabetics/*blood
MH  - Prenatal Exposure Delayed Effects/*blood/physiopathology
MH  - Waist Circumference
PMC - PMC6421132
MID - NIHMS1518795
OTO - NOTNLM
OT  - Adiposity
OT  - Childhood obesity
OT  - Glucose
OT  - Pregnancy
EDAT- 2019/01/17 06:00
MHDA- 2020/02/19 06:00
PMCR- 2020/04/01
CRDT- 2019/01/17 06:00
PHST- 2018/09/21 00:00 [received]
PHST- 2018/12/12 00:00 [accepted]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 10.1007/s00125-018-4809-6 [pii]
AID - 10.1007/s00125-018-4809-6 [doi]
PST - ppublish
SO  - Diabetologia. 2019 Apr;62(4):598-610. doi: 10.1007/s00125-018-4809-6. Epub 2019 
      Jan 15.