PMID- 30649532
OWN - NLM
STAT- MEDLINE
DCOM- 20200302
LR  - 20200524
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 219
IP  - 12
DP  - 2019 May 24
TI  - DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or 
      Without Human Immunodeficiency Virus Infection.
PG  - 1959-1962
LID - 10.1093/infdis/jiz023 [doi]
AB  - Epigenetic modifications such as DNA methylation are associated with both human 
      immunodeficiency virus (HIV) infection and type 2 diabetes mellitus (T2DM). We 
      investigated epigenetic associations with T2DM according to HIV infection status 
      and assessed interaction effects among 681 male participants of the Veterans 
      Aging Cohort Study. Methylation at previously reported sites, cg1963031 (TXNIP), 
      cg18181703 (SOCS3), and cg09152259 (PROC), was significantly associated with T2DM 
      in HIV-infected individuals. We identified 3 novel associations with suggestive 
      statistical significance: cg1231141 (ADAMTS2), cg19534769 (HGFAC), and cg13163919 
      (TLE3). Suggestive interaction with HIV infection status was found at cg17862404 
      (TSC22D1). The implicated genes are involved in inflammation, pancreatic beta-cell 
      function, and T2DM pathogenesis.
CI  - (c) The Author(s) 2019. Published by Oxford University Press for the Infectious 
      Diseases Society of America. All rights reserved. For permissions, e-mail: 
      journals.permissions@oup.com.
FAU - Mathur, Raina
AU  - Mathur R
AD  - Department of Epidemiology, Emory University Rollins School of Public Health, 
      Atlanta.
FAU - Hui, Qin
AU  - Hui Q
AD  - Department of Epidemiology, Emory University Rollins School of Public Health, 
      Atlanta.
FAU - Huang, Yunfeng
AU  - Huang Y
AD  - Department of Epidemiology, Emory University Rollins School of Public Health, 
      Atlanta.
FAU - Gwinn, Marta
AU  - Gwinn M
AD  - Department of Epidemiology, Emory University Rollins School of Public Health, 
      Atlanta.
FAU - So-Armah, Kaku
AU  - So-Armah K
AD  - Department Global Health, Emory University Rollins School of Public Health, 
      Atlanta.
FAU - Freiberg, Matthew S
AU  - Freiberg MS
AD  - Division of Infectious Diseases, Emory University School of Medicine, Atlanta.
FAU - Justice, Amy C
AU  - Justice AC
AD  - Department of Biomedical Informatics, Emory University School of Medicine, 
      Atlanta.
AD  - Atlanta Veterans Affairs Medical Center, Georgia.
FAU - Xu, Ke
AU  - Xu K
AD  - Department of Biomedical Informatics, Emory University School of Medicine, 
      Atlanta.
AD  - Boston University School of Medicine, Massachusetts.
FAU - Marconi, Vincent C
AU  - Marconi VC
AD  - Cardiovascular Medicine Division, Vanderbilt University School of Medicine and 
      Tennessee Valley Healthcare System, Nashville.
AD  - Connecticut Veteran Health System, West Haven.
AD  - Department of Psychiatry, New Haven, Connecticut.
FAU - Sun, Yan V
AU  - Sun YV
AD  - Department of Epidemiology, Emory University Rollins School of Public Health, 
      Atlanta.
AD  - Cardiovascular Medicine Division, Vanderbilt University School of Medicine and 
      Tennessee Valley Healthcare System, Nashville.
AD  - Yale School of Medicine, New Haven, Connecticut.
LA  - eng
GR  - K12 DA000167/DA/NIDA NIH HHS/United States
GR  - P30 AI050409/AI/NIAID NIH HHS/United States
GR  - R03 DA039745/DA/NIDA NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - K01 HL134147/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Cohort Studies
MH  - DNA Methylation/*genetics
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/*genetics
MH  - Epigenesis, Genetic/*genetics
MH  - Genetic Markers/genetics
MH  - HIV Infections/complications/epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Veterans/*statistics & numerical data
PMC - PMC6534194
OTO - NOTNLM
OT  - DNA methylation
OT  - HIV
OT  - Type 2 Diabetes
OT  - epigenome
EDAT- 2019/01/17 06:00
MHDA- 2020/03/03 06:00
PMCR- 2020/05/24
CRDT- 2019/01/17 06:00
PHST- 2018/08/22 00:00 [received]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2020/03/03 06:00 [medline]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2020/05/24 00:00 [pmc-release]
AID - 5288496 [pii]
AID - jiz023 [pii]
AID - 10.1093/infdis/jiz023 [doi]
PST - ppublish
SO  - J Infect Dis. 2019 May 24;219(12):1959-1962. doi: 10.1093/infdis/jiz023.