PMID- 30649534
OWN - NLM
STAT- MEDLINE
DCOM- 20200701
LR  - 20200701
IS  - 1742-3406 (Electronic)
IS  - 0144-8420 (Linking)
VI  - 185
IP  - 2
DP  - 2019 Dec 23
TI  - 10-MV SBRT FFF IRRADIATION TECHNIQUE IS ASSOCIATED TO THE LOWEST PERIPHERAL DOSE: 
      THE OUTCOME OF 142 TREATMENT PLANS FOR THE 10 MOST COMMON TUMOUR LOCATIONS.
PG  - 183-195
LID - 10.1093/rpd/ncy292 [doi]
AB  - There is a growing interest in the combined use of Stereotactic Body Radiation 
      Therapy (SBRT) with Flattening Filter Free (FFF) due to the high local control 
      rates and reduced treatment times, compared to conventionally fractionated 
      treatments. It has been suggested that they may also provide a better radiation 
      protection to radiotherapy patients as a consequence of the expected decrease in 
      peripheral doses. This work aims to determine this reduction in unattended 
      out-of-field regions, where no CT information is available but an important 
      percentage of second primary cancers occur. For that purpose, ten different cases 
      suitable for SBRT were chosen. Thus, 142 different treatment plans including 
      SBRT, as well as 3D-CRT, IMRT and VMAT (with standard fractionation) in low and 
      high energies for Varian (FF and FFF), Siemens and Elekta machines were created. 
      Then, photon and neutron peripheral dose in 14 organs were assessed and compared 
      using two analytical models. For the prostate case, uncomplicated and cancer free 
      control probability estimation was also carried out. As a general behavior, SBRT 
      plans led to the lowest peripheral doses followed by 3D-CRT, VMAT and IMRT, in 
      this order. Unflattened beams proved to be the most effective in reducing 
      peripheral doses, especially for 10 MV. The obtained results suggest that FFF 
      beams for SBRT with 10 MV represent the best compromise between dose delivery 
      efficiency and peripheral dose reduction.
CI  - (c) The Author(s) 2019. Published by Oxford University Press. All rights reserved. 
      For Permissions, please email: journals.permissions@oup.com.
FAU - Irazola, L
AU  - Irazola L
AD  - Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad 
      de Sevilla, Sevilla, Spain.
AD  - Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
FAU - Sanchez-Nieto, B
AU  - Sanchez-Nieto B
AD  - Instituto de Fisica, Pontificia Universidad Catolica de Chile, Santiago, Chile.
FAU - Garcia-Hernandez, M T
AU  - Garcia-Hernandez MT
AD  - Servicio de Radiofisica ERESA, Hospital General Universitario, Valencia, Spain.
FAU - Terron, J A
AU  - Terron JA
AD  - Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad 
      de Sevilla, Sevilla, Spain.
AD  - Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
FAU - Rosello, J
AU  - Rosello J
AD  - Servicio de Radiofisica ERESA, Hospital General Universitario, Valencia, Spain.
FAU - Ortiz-Seidel, M
AU  - Ortiz-Seidel M
AD  - Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad 
      de Sevilla, Sevilla, Spain.
AD  - Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
FAU - Bejar, M J
AU  - Bejar MJ
AD  - Servicio de Radiofisica, Hospital Universitario Ramon y Cajal, Madrid, Spain.
FAU - Linares, R
AU  - Linares R
AD  - Servicio de Radiofisica, Hospital Infanta Luisa, Sevilla, Spain.
FAU - Velazquez, S
AU  - Velazquez S
AD  - Servicio de Radiofisica, Hospital Universitario Virgen del Rocio, Sevilla Spain.
FAU - Sanchez-Doblado, F
AU  - Sanchez-Doblado F
AD  - Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad 
      de Sevilla, Sevilla, Spain.
AD  - Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Radiat Prot Dosimetry
JT  - Radiation protection dosimetry
JID - 8109958
SB  - IM
MH  - Filtration/*instrumentation/methods
MH  - Humans
MH  - Incidence
MH  - Neoplasms/classification/pathology/*surgery
MH  - Neoplasms, Second Primary/diagnosis/*epidemiology
MH  - Organs at Risk/radiation effects
MH  - Prognosis
MH  - Radiosurgery/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Spain/epidemiology
EDAT- 2019/01/17 06:00
MHDA- 2020/07/02 06:00
CRDT- 2019/01/17 06:00
PHST- 2018/06/04 00:00 [received]
PHST- 2018/12/06 00:00 [revised]
PHST- 2018/12/30 00:00 [accepted]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2020/07/02 06:00 [medline]
PHST- 2019/01/17 06:00 [entrez]
AID - 5288302 [pii]
AID - 10.1093/rpd/ncy292 [doi]
PST - ppublish
SO  - Radiat Prot Dosimetry. 2019 Dec 23;185(2):183-195. doi: 10.1093/rpd/ncy292.