PMID- 30651204
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 210
DP  - 2019 Aug
TI  - Clinical and functional long-term outcome of patients at clinical high risk (CHR) 
      for psychosis without transition to psychosis: A systematic review.
PG  - 39-47
LID - S0920-9964(18)30743-6 [pii]
LID - 10.1016/j.schres.2018.12.047 [doi]
AB  - BACKGROUND: Research on patients at clinical high risk (CHR) for psychosis has so 
      far mainly focused on those with transition to frank psychosis (CHR-T patients). 
      However, the majority of CHR patients do not transition (CHR-NT patients) and 
      relatively little information is available on their clinical and functional 
      outcome. METHODS: We conducted a systematic review on clinical and functional 
      long-term outcome of CHR-NT patients. Studies were included if they had an 
      average follow-up period of at least 24 months and reported on long-term outcome 
      of CHR-NT patients in one or more of the following domains: (non-)remission from 
      CHR, prevalence of clinical symptoms and/or clinical diagnoses (axis I and II), 
      and psychosocial functioning. RESULTS: Ten publications from seven different 
      single or multicenter studies with average follow-up durations of 2-7.5 years 
      could be included. At the last follow-up assessment 28-71% of CHR-NT patients 
      were not remitted from their CHR and 22-82% still had at least one clinical 
      diagnosis. Approximately half of CHR-NT patients presented with poor psychosocial 
      outcome at 2-year and 6-year follow-up. CONCLUSIONS: The results suggest that, in 
      the long-term, the majority of CHR-NT patients are not in full clinical remission 
      and seem to suffer from one or more clinical disorders and psychosocial 
      impairments. Since relatively few studies could be identified, further research 
      is required to better understand the trajectories and clinical needs of CHR-NT 
      patients.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Beck, Katharina
AU  - Beck K
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland; University of Basel, Division of Clinical 
      Psychology and Epidemiology, Department of Psychology, Basel, Switzerland.
FAU - Andreou, Christina
AU  - Andreou C
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland.
FAU - Studerus, Erich
AU  - Studerus E
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland.
FAU - Heitz, Ulrike
AU  - Heitz U
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland; University of Basel, Division of Clinical 
      Psychology and Epidemiology, Department of Psychology, Basel, Switzerland.
FAU - Ittig, Sarah
AU  - Ittig S
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland.
FAU - Leanza, Letizia
AU  - Leanza L
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland; University of Basel, Division of Clinical 
      Psychology and Epidemiology, Department of Psychology, Basel, Switzerland.
FAU - Riecher-Rossler, Anita
AU  - Riecher-Rossler A
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland. Electronic address: anita.riecher@upkbs.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20190114
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - *Disease Progression
MH  - Humans
MH  - *Outcome Assessment, Health Care
MH  - *Psychotic Disorders/diagnosis/epidemiology/physiopathology
OTO - NOTNLM
OT  - Non-converters
OT  - Non-psychotic disorders
OT  - Prodromal
OT  - Psychosocial
OT  - Remission
EDAT- 2019/01/18 06:00
MHDA- 2020/09/29 06:00
CRDT- 2019/01/18 06:00
PHST- 2018/05/17 00:00 [received]
PHST- 2018/10/09 00:00 [revised]
PHST- 2018/12/25 00:00 [accepted]
PHST- 2019/01/18 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2019/01/18 06:00 [entrez]
AID - S0920-9964(18)30743-6 [pii]
AID - 10.1016/j.schres.2018.12.047 [doi]
PST - ppublish
SO  - Schizophr Res. 2019 Aug;210:39-47. doi: 10.1016/j.schres.2018.12.047. Epub 2019 
      Jan 14.