PMID- 30651863
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 17
IP  - 1
DP  - 2019 Jan
TI  - Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues.
PG  - 782-790
LID - 10.3892/etm.2018.7027 [doi]
AB  - Epidermal growth factor receptor (EGFR), cyclin D1 and KRAS proto-oncogene, 
      GTPase (KRAS) genes serve roles in the occurrence and development of tumors. The 
      aim of the current study was to investigate the expression levels of EGFR, cyclin 
      D1 and KRAS in laryngocarcinoma tissues and their association with clinical 
      features. In addition, correlation between the expression levels of EGFR, cyclin 
      D1 and KRAS was analyzed in laryngocarcinoma tissues. The expression levels of 
      EGFR, cyclin D1 and KRAS in 46 patients with laryngocarcinoma and 20 patients 
      with vocal cord polyps as the control group were determined using Super Vision 
      immunohistochemical staining assay kits. The differences in clinical and 
      pathological parameters between groups were statistically analyzed using SPSS 
      software version 16.0. The expression rates of EGFR, cyclin D1 and KRAS were 
      71.7, 52.2 and 39.1%, respectively in laryngocarcinoma tissues, and 10.0, 5.0 and 
      10.0%, respectively in vocal cord polyps. There was a positive correlation 
      between the expression levels of EGFR, cyclin D1 and KRAS. The expression of 
      these genes was also closely associated with the clinical stage, treatment 
      response and prognosis of patients with laryngocarcinoma. Multivariate analysis 
      of prognosis using the Cox regression model indicated that EGFR expression in 
      laryngocarcinoma tissues and the clinical stage of patients with laryngocarcinoma 
      were closely associated with patient prognosis. The results of the current study 
      indicated that EGFR, cyclin D1 and KRAS were synergistically involved in the 
      occurrence and development of laryngocarcinoma, directly affecting the prognosis 
      of patients. Additionally, high expression of EGFR, cyclin D1 and KRAS 
      facilitated the invasion and metastasis of laryngocarcinoma cells. The expression 
      of EGFR in laryngocarcinoma tissues and clinical stage were two independent risk 
      factors affecting the prognosis of patients.
FAU - Lin, Xinsheng
AU  - Lin X
AD  - Department of Otolaryngology-Head and Neck Surgery, Shantou Central Hospital, 
      Shantou, Guangdong 515031, P.R. China.
FAU - Wen, Guofeng
AU  - Wen G
AD  - Department of Otolaryngology-Head and Neck Surgery, Shantou Central Hospital, 
      Shantou, Guangdong 515031, P.R. China.
FAU - Wang, Shuangle
AU  - Wang S
AD  - Department of Otolaryngology-Head and Neck Surgery, Shantou Central Hospital, 
      Shantou, Guangdong 515031, P.R. China.
FAU - Lu, Hangui
AU  - Lu H
AD  - Department of Otolaryngology-Head and Neck Surgery, Shantou Central Hospital, 
      Shantou, Guangdong 515031, P.R. China.
FAU - Li, Chuangwei
AU  - Li C
AD  - Department of Otolaryngology-Head and Neck Surgery, Shantou Central Hospital, 
      Shantou, Guangdong 515031, P.R. China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin 
      University, Changchun, Jilin 130000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20181128
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6307426
OTO - NOTNLM
OT  - GTPase
OT  - KRAS proto-oncogene
OT  - cyclin D1
OT  - epidermal growth factor receptor
OT  - laryngocarcinoma
OT  - prognosis
EDAT- 2019/01/18 06:00
MHDA- 2019/01/18 06:01
PMCR- 2018/11/28
CRDT- 2019/01/18 06:00
PHST- 2018/06/06 00:00 [received]
PHST- 2018/10/26 00:00 [accepted]
PHST- 2019/01/18 06:00 [entrez]
PHST- 2019/01/18 06:00 [pubmed]
PHST- 2019/01/18 06:01 [medline]
PHST- 2018/11/28 00:00 [pmc-release]
AID - ETM-0-0-7027 [pii]
AID - 10.3892/etm.2018.7027 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Jan;17(1):782-790. doi: 10.3892/etm.2018.7027. Epub 2018 Nov 
      28.