PMID- 30651975
OWN - NLM
STAT- MEDLINE
DCOM- 20200302
LR  - 20200309
IS  - 2047-2994 (Electronic)
IS  - 2047-2994 (Linking)
VI  - 8
DP  - 2019
TI  - HIV infection in Xi'an, China: epidemic characterization, risk factors to false 
      positives and potential utility of the sample-to-cutoff index to identify true 
      positives using Architect HIV Ag/Ab combo.
PG  - 9
LID - 10.1186/s13756-019-0463-0 [doi]
LID - 9
AB  - BACKGROUND: In China, although tremendous efforts has been made, the HIV/AIDS is 
      still not controlled. OBJECTIVES: The study was carried out to determine the 
      epidemic of HIV infection in Xi'an, analyse false positives (FP) risk factors and 
      potential utility of sample-to-cutoff index to identify true positives using 
      Architect HIV Ag/Ab Combo. METHODS: A retrospective review for HIV screening by 
      Architect HIV Ag/Ab Combo was performed in a teaching hospital in Xi'an between 
      2015 and 2016. The prevalence of HIV, positive predictive value (PPV) at 
      different cut-off indexices (COI) were calculated. The epidemic of infections and 
      risk factors for FP results were investigated. RESULTS: In the study, the HIV 
      prevalence and FP rate of Architect HIV Ag/Ab Combo were 0.076 and 46.08%, 
      respectively. The Han Chinese, males and people aged < 40 years accounted for the 
      majority of infections (98.29, 76.07 and 73.5%, respectively). 85.47% of the 
      infections were transmitted through sexual contact (35.04% of male homosexual and 
      50.43% of heterosexual). COI at 1-10, 10-30 and >/= 30, the PPVs were 0, 50 and 
      100%, respectively. The independent risk factors for FP, i.e., pregnancy and 
      malignancy had a statistically significant association with FP (p < 0.05), and 
      age had a very strong statistically significant association with FP (p < 0.001). 
      CONCLUSIONS: In Xi'an, sexual contact was the most important transmission mode 
      for HIV, and the infections were predominantly identified in Han Chinese, males, 
      young and middle-aged people. For Architect HIV Ag/Ab Combo, it can achieve 100% 
      of PPV with COI >/=30, and the age was strongly statistically associated with FP.
FAU - Wang, Linchuan
AU  - Wang L
AD  - 1Clinical Laboratory of the First Affiliated Hospital of Xi'an Jiaotong 
      University, Yan Ta Road No 277, Xi'an, Shaanxi Province China.
FAU - Xiao, Yao
AU  - Xiao Y
AD  - 1Clinical Laboratory of the First Affiliated Hospital of Xi'an Jiaotong 
      University, Yan Ta Road No 277, Xi'an, Shaanxi Province China.
FAU - Tian, Xu-Dong
AU  - Tian XD
AD  - 1Clinical Laboratory of the First Affiliated Hospital of Xi'an Jiaotong 
      University, Yan Ta Road No 277, Xi'an, Shaanxi Province China.
FAU - Ruan, Jin-Xiong
AU  - Ruan JX
AD  - 1Clinical Laboratory of the First Affiliated Hospital of Xi'an Jiaotong 
      University, Yan Ta Road No 277, Xi'an, Shaanxi Province China.
FAU - Chen, Wei
AU  - Chen W
AD  - 1Clinical Laboratory of the First Affiliated Hospital of Xi'an Jiaotong 
      University, Yan Ta Road No 277, Xi'an, Shaanxi Province China.
FAU - Yu, Yan
AU  - Yu Y
AD  - 2Inspection Department of Hong-Hui Hospital, Xi'an Jiaotong University College of 
      Medicine, Nan Guo Road No 76, Xi'an, Shaanxi Province China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190111
PL  - England
TA  - Antimicrob Resist Infect Control
JT  - Antimicrobial resistance and infection control
JID - 101585411
RN  - 0 (HIV Antibodies)
RN  - 0 (HIV Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology/ethnology
MH  - False Positive Reactions
MH  - Female
MH  - HIV Antibodies/*blood
MH  - HIV Antigens/*blood
MH  - HIV Infections/blood/*diagnosis/epidemiology/ethnology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serologic Tests
MH  - Young Adult
PMC - PMC6329139
OTO - NOTNLM
OT  - Architect HIV ag/ab combo
OT  - False positives
OT  - HIV epidemic
COIS- The study was deemed exempt from review by the Ethics Committee of the First 
      Affiliated Hospital of Xi'an Jiaotong University as routine data for clinical 
      purposes were used, and all patient information remained confidential in the 
      study.LW, YX, XDT, JR, YY and WC have read and approved the final manuscript for 
      publication in Antimicrobial Resistance & Infection Control.LW, YX, XDT, JR, YY 
      and WC declare that they have no competing interest.Springer Nature remains 
      neutral with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2019/01/18 06:00
MHDA- 2020/03/03 06:00
PMCR- 2019/01/11
CRDT- 2019/01/18 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2019/01/03 00:00 [accepted]
PHST- 2019/01/18 06:00 [entrez]
PHST- 2019/01/18 06:00 [pubmed]
PHST- 2020/03/03 06:00 [medline]
PHST- 2019/01/11 00:00 [pmc-release]
AID - 463 [pii]
AID - 10.1186/s13756-019-0463-0 [doi]
PST - epublish
SO  - Antimicrob Resist Infect Control. 2019 Jan 11;8:9. doi: 
      10.1186/s13756-019-0463-0. eCollection 2019.