PMID- 30652394
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201005
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 21
IP  - 9
DP  - 2019 Sep
TI  - Cardiac contractility modulation improves long-term survival and hospitalizations 
      in heart failure with reduced ejection fraction.
PG  - 1103-1113
LID - 10.1002/ejhf.1374 [doi]
AB  - AIMS: Cardiac contractility modulation (CCM) improves symptoms and exercise 
      tolerance and reduces heart failure (HF) hospitalizations over 6-month follow-up 
      in patients with New York Heart Association (NYHA) class III or IV symptoms, QRS 
      < 130 ms and 25% </= left ventricular ejection fraction (LVEF) </= 45% (FIX-HF-5C 
      study). The current prospective registry study (CCM-REG) aimed to assess the 
      longer-term impact of CCM on hospitalizations and mortality in real-world 
      experience in this same population. METHODS AND RESULTS: A total of 140 patients 
      with 25% </= LVEF </= 45% receiving CCM therapy (CCM-REG(25-45) ) for clinical 
      indications were included. Cardiovascular and HF hospitalizations, Minnesota 
      Living with Heart Failure Questionnaire (MLHFQ) and NYHA class were assessed over 
      2 years. Mortality was tracked through 3 years and compared with predictions by 
      the Seattle Heart Failure Model (SHFM). A separate analysis was performed on 
      patients with 35% </= LVEF </= 45% (CCM-REG(35-45) ) and 25% </= LVEF < 35% 
      (CCM-REG(25-34) ). Hospitalizations decreased by 75% (from 1.2/patient-year the 
      year before, to 0.35/patient-year during the 2 years following CCM, P < 0.0001) 
      in CCM-REG(25-45) and by a similar amount in CCM-REG(35-45) (P < 0.0001) and 
      CCM-REG(25-34) . MLHFQ and NYHA class improved in all three cohorts(,) with 
      progressive improvements over time (P < 0.002). Three-year survival in 
      CCM-REG(25-45) (82.8%) and CCM-REG(24-34) (79.4%) were similar to those predicted 
      by SHFM (76.7%, P = 0.16; 78.0%, P = 0.81, respectively) and was better than 
      predicted in CCM-REG(35-45) (88.0% vs. 74.7%, P = 0.046). CONCLUSION: In 
      real-world experience, CCM produces results similar to those of previous studies 
      in subjects with 25% </= LVEF </= 45% and QRS < 130 ms; cardiovascular and HF 
      hospitalizations are reduced and MLHFQ and NYHA class are improved. Overall 
      mortality was comparable to that predicted by the SHFM but was lower than 
      predicted in patients with 35% </= LVEF </= 45%.
CI  - (c) 2019 The Authors. European Journal of Heart Failure (c) 2019 European Society of 
      Cardiology.
FAU - Anker, Stefan D
AU  - Anker SD
AD  - Division of Cardiology and Metabolism; Department of Cardiology (CVK; and 
      Berlin-Brandenburg Center for Regenerative Therapies (BCRT), German Centre for 
      Cardiovascular Research (DZHK) partner site Berlin, Charite Universitatsmedizin 
      Berlin, Berlin, Germany.
AD  - Department of Cardiology and Pneumology and The German Center for Cardiovascular 
      Research (DZHK), University Medicine Gottingen (UMG), Gottingen, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - First Department of Medicine, University Medical Centre Mannheim (UMM), Mannheim, 
      Germany.
AD  - Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
AD  - DZHK (German Centre for Cardiovascular Research) Partner Site 
      Heidelberg/Mannheim, Mannheim, Germany.
FAU - Neuser, Hans
AU  - Neuser H
AD  - HELIOS Vogtland-Klinikum Plauen, Klinik fur Innere Medizin II/Kardiologie, 
      Pneumologie und Angiologie, Plauen, Germany.
FAU - Ohlow, Marc-Alexander
AU  - Ohlow MA
AD  - Zentralklinik Bad Berka GmbH, Bad Berka, Germany.
FAU - Roger, Susanne
AU  - Roger S
AD  - First Department of Medicine, University Medical Centre Mannheim (UMM), Mannheim, 
      Germany.
AD  - Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
AD  - DZHK (German Centre for Cardiovascular Research) Partner Site 
      Heidelberg/Mannheim, Mannheim, Germany.
FAU - Goette, Andreas
AU  - Goette A
AD  - St. Vincenz Krankenhaus Paderborn, Paderborn, Germany.
AD  - Working Group of Molecular Electrophysiology, University Hospital Magdeburg, 
      Magdeburg, Germany.
FAU - Remppis, Bjoern A
AU  - Remppis BA
AD  - Herz- und Gefasszentrum Bad Bevensen, Bad Bevensen, Germany.
FAU - Kuck, Karl-Heinz
AU  - Kuck KH
AD  - Asklepios Klinik St. Georg, Hamburg, Germany.
FAU - Najarian, Kevin B
AU  - Najarian KB
AD  - Independent Statistical Consultant, Boston, MA, USA.
FAU - Gutterman, David D
AU  - Gutterman DD
AD  - Medical College of Wisconsin, Milwaukee, WI, USA.
FAU - Rousso, Benny
AU  - Rousso B
AD  - Scientific Consultant, Hod Hasharon, Israel.
FAU - Burkhoff, Daniel
AU  - Burkhoff D
AD  - Cardiovascular Research Foundation, New York, NY, USA.
FAU - Hasenfuss, Gerd
AU  - Hasenfuss G
AD  - Department of Cardiology and Pneumology and The German Center for Cardiovascular 
      Research (DZHK), University Medicine Gottingen (UMG), Gottingen, Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20190116
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
CIN - Eur J Heart Fail. 2019 Sep;21(9):1114-1116. PMID: 31407843
MH  - Aged
MH  - Electric Stimulation Therapy/*methods
MH  - Female
MH  - Heart Failure/physiopathology/*therapy
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mortality
MH  - Myocardial Contraction
MH  - *Quality of Life
MH  - Stroke Volume
OTO - NOTNLM
OT  - Hospitalizations
OT  - Left ventricular ejection fraction
OT  - Minnesota Living with Heart Failure Questionnaire
OT  - Survival
EDAT- 2019/01/18 06:00
MHDA- 2020/10/06 06:00
CRDT- 2019/01/18 06:00
PHST- 2018/08/06 00:00 [received]
PHST- 2018/10/23 00:00 [revised]
PHST- 2018/11/04 00:00 [accepted]
PHST- 2019/01/18 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2019/01/18 06:00 [entrez]
AID - 10.1002/ejhf.1374 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2019 Sep;21(9):1103-1113. doi: 10.1002/ejhf.1374. Epub 2019 Jan 
      16.