PMID- 30652784
OWN - NLM
STAT- MEDLINE
DCOM- 20190222
LR  - 20190222
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 52
DP  - 2019 Jan 14
TI  - Natural history of experimental arthritis induced by Paracoccidioides 
      brasiliensis in wistar rats.
PG  - e20180043
LID - S0037-86822019000100600 [pii]
LID - 10.1590/0037-8682-0043-2018 [doi]
AB  - INTRODUCTION: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis 
      in Latin America. This study aimed to evaluate the natural history of 
      Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints 
      in Wistar rats. METHODS: Rats were randomly allocated to either an absolute 
      control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) 
      groups. RESULTS: Experimental groups developed classic signs of articular PCM. 
      Titers of anti-gp43 were observed to increase during the interval from 15 to 45 
      days post-inoculation. CONCLUSIONS: Articular arthritic lesions were induced and 
      progressed during the study period in all experimental groups.
FAU - Loth, Eduardo Alexandre
AU  - Loth EA
AD  - Laboratorio Experimental de Microbiologia e Analises Clinicas, Ensino, Pesquisa e 
      Extensao, Universidade Estadual do Oeste do Parana, Cascavel, PR, Brasil.
FAU - Cecatto, Vanessa
AU  - Cecatto V
AD  - Laboratorio Experimental de Microbiologia e Analises Clinicas, Ensino, Pesquisa e 
      Extensao, Universidade Estadual do Oeste do Parana, Cascavel, PR, Brasil.
FAU - Genske, Rodrigo Daniel
AU  - Genske RD
AD  - Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao 
      Jose dos Campos, SP, Brasil.
FAU - Costa, Maricilia Silva
AU  - Costa MS
AD  - Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao 
      Jose dos Campos, SP, Brasil.
FAU - Gandra, Rinaldo Ferreira
AU  - Gandra RF
AD  - Laboratorio Experimental de Microbiologia e Analises Clinicas, Ensino, Pesquisa e 
      Extensao, Universidade Estadual do Oeste do Parana, Cascavel, PR, Brasil.
FAU - Pilatti, Cleverson Marcelo
AU  - Pilatti CM
AD  - Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao 
      Jose dos Campos, SP, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20190114
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/*microbiology/pathology
MH  - Arthritis, Infectious/*microbiology/pathology
MH  - *Paracoccidioidomycosis
MH  - Rats
MH  - Rats, Wistar
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2019/01/18 06:00
MHDA- 2019/02/23 06:00
CRDT- 2019/01/18 06:00
PHST- 2018/02/05 00:00 [received]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2019/01/18 06:00 [entrez]
PHST- 2019/01/18 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
AID - S0037-86822019000100600 [pii]
AID - 10.1590/0037-8682-0043-2018 [doi]
PST - epublish
SO  - Rev Soc Bras Med Trop. 2019 Jan 14;52:e20180043. doi: 
      10.1590/0037-8682-0043-2018.