PMID- 30653163
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 3
DP  - 2019 Jan
TI  - Marfan syndrome with type 2 diabetes mellitus: A case report from China.
PG  - e14176
LID - 10.1097/MD.0000000000014176 [doi]
LID - e14176
AB  - RATIONALE: Marfan syndrome (MFS) is a genetic disorder of the connective tissue. 
      MFS has an incidence of about 2 to 3 persons per 10,000 population. MFS is 
      characterized majorly by the involvement of the eyes, skeletal muscles, and 
      cardiovascular system. There are limited case reports of co-existence of MFS and 
      type 2 diabetes mellitus (T2DM). PATIENT CONCERNS: A 16-year-old male patient who 
      got admitted to our hospital with complaints of loss of vision from left eye for 
      the last 3 days.Diagnosis of MFS along with luxation of left eye lens, and T2DM 
      were made according to the patient's symptoms, signs, biochemical results, and 
      ultrasonography. INTERVENTIONS: The patient received "vitrectomy (posterior 
      approach (left eye)) + cataract extraction (left eye) + intraocular lens 
      implantation (left eye) surgery" for luxation of left eye lens. The patient 
      received "Bentall Operation" for MFS, and was prescribed warfarin 5 mg qod and 
      spironolactone 20 mg bid during the follow-up period. The patient received 
      continuous subcutaneous insulin infusion (CSII) during hospitalization, and then 
      changed to insulin glargine preparation during the follow-up period. OUTCOMES: 
      The vision was restored after the eye surgery and the patient also recovered well 
      after the Bentall Operation. Additionally, there were no obvious complications 
      during hospitalization and the follow-up period. Blood glucose levels were within 
      normal range. LESSONS: There is a need to improve the recognition of MFS among 
      school and community doctors. Early detection, diagnosis, and treatment of this 
      rare disease can improve the quality of patient's life.
FAU - Zhou, Yingyi
AU  - Zhou Y
AD  - Endocrine Department, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Du, Xuan
AU  - Du X
FAU - Chen, Chao
AU  - Chen C
FAU - Shi, Bimin
AU  - Shi B
FAU - Chen, Ke
AU  - Chen K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Cataract/complications
MH  - Cataract Extraction/methods
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/therapy
MH  - Humans
MH  - Insulin/therapeutic use
MH  - Lens Implantation, Intraocular/methods
MH  - Lens Subluxation/complications/surgery
MH  - Male
MH  - Marfan Syndrome/*complications/diagnosis/therapy
MH  - Vitrectomy/methods
PMC - PMC6370063
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/01/18 06:00
MHDA- 2019/01/29 06:00
PMCR- 2019/01/18
CRDT- 2019/01/18 06:00
PHST- 2019/01/18 06:00 [entrez]
PHST- 2019/01/18 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2019/01/18 00:00 [pmc-release]
AID - 00005792-201901180-00078 [pii]
AID - MD-D-18-04684 [pii]
AID - 10.1097/MD.0000000000014176 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Jan;98(3):e14176. doi: 10.1097/MD.0000000000014176.