PMID- 30655200 OWN - NLM STAT- MEDLINE DCOM- 20200420 LR - 20200420 IS - 1532-8422 (Electronic) IS - 1053-0770 (Linking) VI - 33 IP - 7 DP - 2019 Jul TI - Coagulation Derangements in Patients With Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation. PG - 1877-1882 LID - S1053-0770(18)31031-0 [pii] LID - 10.1053/j.jvca.2018.11.014 [doi] AB - OBJECTIVE: Extracorporeal cardiopulmonary resuscitation (eCPR) with venoarterial extracorporeal membrane oxygenation (VA-ECMO) is gaining importance as a rescue therapy for refractory cardiac arrest. VA-ECMO, especially in the setting of eCPR, is plagued by hemorrhagic and thromboembolic complications. The authors' aims were to describe the coagulation profile in refractory cardiac arrest and assess its prognostic role. DESIGN: Single-center retrospective study. SETTING: Cardiac surgical intensive care unit of a university hospital. PARTICIPANTS: One hundred eighty-eight patients treated with eCPR for intra-hospital and out-of-hospital refractory cardiac arrest, between 2008 and 2017. INTERVENTIONS: The authors retrospectively analyzed data from the first blood sample drawn during cannulation for VA-ECMO to understand the association of coagulation parameters with survival to hospital discharge, number of blood components transfused, anticoagulation therapy, serum lactate levels, no-flow time, and low-flow time. MEASUREMENTS AND MAIN RESULTS: Platelet count was 126 +/- 79 x 10(9)/L and in 17% of the population it was lower than 50 x 10(9)/L, prothrombin time was 3.22 +/- 4.01, activated partial thromboplastin time was 117 +/- 78 seconds, fibrinogen was 186 +/- 148 mg/dL, antithrombin was 47 +/- 16%, and D-dimer was >/=2-fold the normal upper limit in 95% of patients. Fifty percent of patients had a disseminated intravascular coagulation (DIC) score >/=6 (52% among out-of-hospital cardiac arrest, 33% among in-hospital cardiac arrest), according to the criteria of the Japanese Society on Thrombosis and Hemostasis (2016). The median DIC score was 5.5 points (interquartile range 4-8), significantly different between survivors and nonsurvivors (4 [3-6] v 6 [4-8], p = 0.007). Every DIC score point contributed to the mortality risk (OR 1.34, 95% CI 1.09-1.67, p = 0.006). Patients with overt DIC less frequently received anticoagulants (28.6% v 55.9%, p = 0.002), started anticoagulant therapy later (12 [10-23] v 8.5 [5-12] hours, p = 0.045), and received a larger quantity of blood products (11 [4-23] v 3 [0-8.5] units, p < 0.0001). CONCLUSION: Coagulation derangements are frequent in patients with refractory cardiac arrest and have important consequences for eCPR management for anticoagulant therapy and blood product transfusion. The presence of DIC diagnostic criteria should be considered among the prognostic factors in this population of patients. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Ruggeri, Laura AU - Ruggeri L AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Franco, Annalisa AU - Franco A AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Alba, Ada Carla AU - Alba AC AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Lembo, Rosalba AU - Lembo R AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Frassoni, Samuele AU - Frassoni S AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Scandroglio, Anna Mara AU - Scandroglio AM AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Calabro, Maria Grazia AU - Calabro MG AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Zangrillo, Alberto AU - Zangrillo A AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Pappalardo, Federico AU - Pappalardo F AD - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: pappalardo.federico@hsr.it. LA - eng PT - Journal Article DEP - 20181114 PL - United States TA - J Cardiothorac Vasc Anesth JT - Journal of cardiothoracic and vascular anesthesia JID - 9110208 SB - IM CIN - J Cardiothorac Vasc Anesth. 2019 Jul;33(7):2098. PMID: 30935768 MH - Adult MH - Aged MH - *Blood Coagulation MH - *Cardiopulmonary Resuscitation MH - Disseminated Intravascular Coagulation/drug therapy MH - *Extracorporeal Membrane Oxygenation MH - Heart Arrest/*therapy MH - Humans MH - Logistic Models MH - Middle Aged MH - Retrospective Studies OTO - NOTNLM OT - cardiac arrest OT - coagulation OT - disseminated intravascular coagulation OT - extracorporeal cardiopulmonary resuscitation OT - extracorporeal membrane oxygenation OT - refractory cardiac arrest EDAT- 2019/01/19 06:00 MHDA- 2020/04/21 06:00 CRDT- 2019/01/19 06:00 PHST- 2018/09/04 00:00 [received] PHST- 2019/01/19 06:00 [pubmed] PHST- 2020/04/21 06:00 [medline] PHST- 2019/01/19 06:00 [entrez] AID - S1053-0770(18)31031-0 [pii] AID - 10.1053/j.jvca.2018.11.014 [doi] PST - ppublish SO - J Cardiothorac Vasc Anesth. 2019 Jul;33(7):1877-1882. doi: 10.1053/j.jvca.2018.11.014. Epub 2018 Nov 14.