PMID- 30656148
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 14
IP  - 6
DP  - 2018 Dec
TI  - Treadmill exercise and wheel exercise improve motor function by suppressing 
      apoptotic neuronal cell death in brain inflammation rats.
PG  - 911-919
LID - 10.12965/jer.1836508.254 [doi]
AB  - Brain inflammation is involved in many brain disorders, such as brain ischemic 
      injury, Alzheimer diseases, and Parkinson disease. Physical exercise has been 
      recommended for the prevention and treatment of many brain inflammatory diseases. 
      In the present study, the effects of exercise on motor function in relation with 
      apoptotic neuronal cell death following neuroinflammation were investigated. 
      Moreover, we compared the effect of forced exercise with voluntary exercise on 
      neuroinflammation-induced motor malfunction. For this study, rota-rod test, 
      vertical pole test, foot fault test, terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) assay, immunohistochemistry 
      for caspase-3, and western blot for Bcl-2 and Bax were performed. 
      Lipopolysaccharide was intraventricular infused for induction of brain 
      inflammation. Treadmill exercise and wheel exercise were conducted during 6 
      weeks. In the present results, Treadmill exercise and wheel exercise alleviated 
      brain inflammation-induced motor impairments by suppressing apoptotic neuronal 
      cell death in the motor cortex. These effects of treadmill exercise and wheel 
      exercise were similarly appeared.
FAU - Song, Sang-Hyuk
AU  - Song SH
AD  - Department of Physical Activity Design, Hanseo University, Seosan, Korea.
FAU - Jee, Yong-Seok
AU  - Jee YS
AD  - Department of Physical Activity Design, Hanseo University, Seosan, Korea.
FAU - Ko, Il-Gyu
AU  - Ko IG
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AD  - Department of Physical Education, Korea Military Academy, Seoul, Korea.
FAU - Sim, Young-Je
AU  - Sim YJ
AD  - Department of Physical Education, Kunsan National University, Gunsan, Korea.
FAU - Kim, Dae-Young
AU  - Kim DY
AD  - Department of Sports Healthcare, College of Humanities & Social Sciences, Inje 
      University, Gimhae, Korea.
FAU - Lee, Sam-Jun
AU  - Lee SJ
AD  - Department of Physical Education, College of Health, Welfare, and Education, Tong 
      Myong University, Busan, Korea.
FAU - Cho, Young Sam
AU  - Cho YS
AUID- ORCID: 0000-0002-2966-7971
AD  - Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20181227
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC6323344
OTO - NOTNLM
OT  - Apoptosis
OT  - Brain inflammation
OT  - Motor function
OT  - Treadmill exercise
OT  - Wheel exercise
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2019/01/19 06:00
MHDA- 2019/01/19 06:01
PMCR- 2018/12/27
CRDT- 2019/01/19 06:00
PHST- 2018/10/24 00:00 [received]
PHST- 2018/11/26 00:00 [accepted]
PHST- 2019/01/19 06:00 [entrez]
PHST- 2019/01/19 06:00 [pubmed]
PHST- 2019/01/19 06:01 [medline]
PHST- 2018/12/27 00:00 [pmc-release]
AID - jer-14-6-911 [pii]
AID - 10.12965/jer.1836508.254 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2018 Dec 27;14(6):911-919. doi: 10.12965/jer.1836508.254. 
      eCollection 2018 Dec.