PMID- 30658461
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 11
IP  - 1
DP  - 2019 Jan 17
TI  - Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of 
      Dendritic Cells.
LID - 10.3390/cancers11010108 [doi]
LID - 108
AB  - Dendritic cells (DCs) are capable of activating adaptive immune responses, or 
      inducing immune suppression or tolerance. In the tumor microenvironment, the 
      function of DCs is polarized into immune suppression that attenuates the effect 
      of T cells, promoting differentiation of regulatory T cells and supporting tumor 
      progression. Therefore, blocking negative immune regulators in DCs is considered 
      a strategy of cancer immunotherapy. Antibodies can target molecules on the cell 
      surface, but not intracellular molecules of DCs. The delivery of short-hairpin 
      RNAs (shRNA) and small-interfering RNAs (siRNA) should be a strategy to silence 
      specific intracellular targets in DCs. This review provides an overview of the 
      known negative immune regulators of DCs. Moreover, a combination of shRNA/siRNA 
      and DC vaccines, DNA vaccines in animal models, and clinical trials are also 
      discussed.
FAU - Liu, Yao-Hua
AU  - Liu YH
AD  - Department of Emergency Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung Medical University, Kaohsiung 807, Taiwan. 980542@ms.kmuh.org.tw.
FAU - Yeh, I-Jeng
AU  - Yeh IJ
AD  - Department of Emergency Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung Medical University, Kaohsiung 807, Taiwan. 910201@ms.kmuh.org.tw.
FAU - Lai, Ming-Derg
AU  - Lai MD
AD  - Department of Biochemistry and Molecular Biology, College of Medicine, National 
      Cheng Kung University, Tainan 701, Taiwan. a1211207@mail.ncku.edu.tw.
AD  - Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung 
      University, Tainan 701, Taiwan. a1211207@mail.ncku.edu.tw.
FAU - Liu, Kuan-Ting
AU  - Liu KT
AD  - Department of Emergency Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung Medical University, Kaohsiung 807, Taiwan. 890077@ms.kmuh.org.tw.
AD  - School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 
      807, Taiwan. 890077@ms.kmuh.org.tw.
FAU - Kuo, Po-Lin
AU  - Kuo PL
AUID- ORCID: 0000-0003-2487-2818
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung 807, Taiwan. kuopolin@seed.net.tw.
FAU - Yen, Meng-Chi
AU  - Yen MC
AD  - Department of Emergency Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung Medical University, Kaohsiung 807, Taiwan. yohoco@gmail.com.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung 807, Taiwan. yohoco@gmail.com.
LA  - eng
GR  - MOST106-2320-B-037-029-MY3/Ministry of Science and Technology, Taiwan/
GR  - KMUH106-6R77/Kaohsiung Medical University Hospital/
PT  - Journal Article
PT  - Review
DEP - 20190117
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC6357062
OTO - NOTNLM
OT  - cancer
OT  - dendritic cells (DCs)
OT  - intracellular negative immune regulator
OT  - short-hairpin RNA (shRNA)
OT  - small-interfering RNA (siRNA)
COIS- The authors declare no conflict of interest.
EDAT- 2019/01/20 06:00
MHDA- 2019/01/20 06:01
PMCR- 2019/01/17
CRDT- 2019/01/20 06:00
PHST- 2018/11/30 00:00 [received]
PHST- 2019/01/09 00:00 [revised]
PHST- 2019/01/13 00:00 [accepted]
PHST- 2019/01/20 06:00 [entrez]
PHST- 2019/01/20 06:00 [pubmed]
PHST- 2019/01/20 06:01 [medline]
PHST- 2019/01/17 00:00 [pmc-release]
AID - cancers11010108 [pii]
AID - cancers-11-00108 [pii]
AID - 10.3390/cancers11010108 [doi]
PST - epublish
SO  - Cancers (Basel). 2019 Jan 17;11(1):108. doi: 10.3390/cancers11010108.