PMID- 30659912
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20191210
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 698
DP  - 2019 Apr 17
TI  - Functional crosstalk of nucleus accumbens CB1 and OX2 receptors in response to 
      nicotine-induced place preference.
PG  - 160-164
LID - S0304-3940(19)30039-4 [pii]
LID - 10.1016/j.neulet.2019.01.027 [doi]
AB  - In the present study, we have evaluated the existence of functional interaction 
      between orexin-2 receptor (OX2R) and cannabinoid-1 receptor (CB1R) in the nucleus 
      accumbens core (NAcc), in nicotine-induced conditioned place preference (CPP) of 
      Wistar male rat. Nicotine (0.5 mg/kg; s.c.) in the course of conditioning, 
      produced a significant place preference, without any effect on the locomotor 
      activity. Intra-NAcc administration of ineffective and effective doses of 
      TCS-OX2-29 (2 and 6 ng/rat), a selective OX2R antagonist and AM251 (10 and 
      50 ng/rat), a selective CB1R antagonist, showed a significant interaction between 
      OX2R and CB1R in the acquisition of nicotine-induced CPP (p < 0.01), and the 
      locomotor activity (p < 0.05). No significant interaction was observed between 
      these two receptors in the expression of nicotine-induced CPP. Our findings 
      provide insight into the possible interaction of OX2R and CB1R of the NAcc in 
      nicotine addiction. We propose a potential interaction between cannabinoid and 
      orexinergic systems within the NAcc, in producing the rewarding effects.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Fartootzadeh, Reza
AU  - Fartootzadeh R
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Azizi, Fatemeh
AU  - Azizi F
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Alaei, Hojjatallah
AU  - Alaei H
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Reisi, Parham
AU  - Reisi P
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran. Electronic address: p_reisi@med.mui.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190116
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Orexin Receptor Antagonists)
RN  - 0 (Orexin Receptors)
RN  - 0 (Piperidines)
RN  - 0 (Pyrazoles)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - 3I4FA44MAI (AM 251)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Conditioning, Psychological/drug effects
MH  - Male
MH  - Nicotine/*pharmacology
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Orexin Receptor Antagonists/pharmacology
MH  - Orexin Receptors/*drug effects/metabolism
MH  - Piperidines/pharmacology
MH  - Pyrazoles/pharmacology
MH  - Rats, Wistar
MH  - Receptor, Cannabinoid, CB1/*antagonists & inhibitors
OTO - NOTNLM
OT  - Cannabinoid receptors
OT  - Condition place preference
OT  - Nicotine
OT  - Nucleus accumbens core
OT  - Orexin receptors
EDAT- 2019/01/20 06:00
MHDA- 2019/09/11 06:00
CRDT- 2019/01/20 06:00
PHST- 2018/08/04 00:00 [received]
PHST- 2018/12/17 00:00 [revised]
PHST- 2019/01/15 00:00 [accepted]
PHST- 2019/01/20 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2019/01/20 06:00 [entrez]
AID - S0304-3940(19)30039-4 [pii]
AID - 10.1016/j.neulet.2019.01.027 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Apr 17;698:160-164. doi: 10.1016/j.neulet.2019.01.027. Epub 
      2019 Jan 16.