PMID- 30659947
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20231213
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 692
DP  - 2019 Apr 15
TI  - Long noncoding RNA MIR31HG is activated by SP1 and promotes cell migration and 
      invasion by sponging miR-214 in NSCLC.
PG  - 223-230
LID - S0378-1119(19)30042-3 [pii]
LID - 10.1016/j.gene.2018.12.077 [doi]
AB  - Long non-coding RNAs(lncRNAs) have been reported to play pivotal roles in various 
      cancers. Recently, MIR31HG was proposed to be involved in tumor progression. 
      However, its role in non small cell lung cancer(NSCLC) remains elusive. In this 
      work, we found that SP1-induced MIR31HG was significantly upregulated in NSCLC 
      tissues and cell lines. Moreover, Cox multivariate survival analysis revealed 
      that high MIR31HG was an independent predictor of poor overall survival(OS). 
      Functionally, knockdown of TINCR obviously suppressed NSCLC cells migration and 
      invasion in vitro and inhibited NSCLC cells metastasis in vivo. Mechanistically, 
      we identified MIR31HG could act as a miR-214 sponge using RNA pull down, 
      luciferase reporter and RIP assays. Lastly, we verified that overexpression of 
      MIR31HG effectively reverses miR-214-induced inhibition of NSCLC cells 
      progression. Therefore, MIR31HG might serve as a promising prognostic marker and 
      potential therapeutic target for NSCLC patients.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Dandan, Wu
AU  - Dandan W
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong 
      University, China.
FAU - Jianliang, Chen
AU  - Jianliang C
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong 
      University, China.
FAU - Haiyan, He
AU  - Haiyan H
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong 
      University, China.
FAU - Hang, Ma
AU  - Hang M
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong 
      University, China.
FAU - Xuedong, Lv
AU  - Xuedong L
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong 
      University, China. Electronic address: lvxuedong226@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190117
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (MIRN214 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Sp1 Transcription Factor)
RN  - 0 (SP1 protein, human)
RN  - 0 (long noncoding RNA MIR31HG, human)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Carcinoma, Non-Small-Cell Lung/genetics/mortality/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/genetics/mortality/*pathology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - RNA, Long Noncoding/*genetics
MH  - Sp1 Transcription Factor/*genetics/metabolism
MH  - Survival Analysis
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - Invasion
OT  - MIR31HG
OT  - Migration
OT  - NSCLC
OT  - miR-214
EDAT- 2019/01/20 06:00
MHDA- 2019/03/06 06:00
CRDT- 2019/01/20 06:00
PHST- 2018/09/10 00:00 [received]
PHST- 2018/12/16 00:00 [revised]
PHST- 2018/12/31 00:00 [accepted]
PHST- 2019/01/20 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2019/01/20 06:00 [entrez]
AID - S0378-1119(19)30042-3 [pii]
AID - 10.1016/j.gene.2018.12.077 [doi]
PST - ppublish
SO  - Gene. 2019 Apr 15;692:223-230. doi: 10.1016/j.gene.2018.12.077. Epub 2019 Jan 17.