PMID- 30661318
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Mar
TI  - Intranasal Treatment With 1, 25-Dihydroxyvitamin D3 Alleviates Allergic Rhinitis 
      Symptoms in a Mouse Model.
PG  - 267-279
LID - 10.4168/aair.2019.11.2.267 [doi]
AB  - PURPOSE: Vitamin D is a potent immunomodulator. However, its role in the 
      pathogenesis of allergic rhinitis is unclear. METHODS: The aim of this study was 
      to evaluate the antiallergic effect of intranasally applied vitamin D in an 
      allergic rhinitis mouse model. BALB/c mice were intraperitoneally sensitized with 
      ovalbumin (OVA) and alum before they were intranasally challenged with OVA. Then, 
      they were intranasally administered 1, 25-dihydroxyvitamin D3 (0.02 mug) or 
      solvent. Allergic symptom scores, eosinophil infiltration, cytokine mRNA levels 
      (interleukin [IL]-4, IL-5, IL-10, IL-13 and interferon-gamma) in the nasal tissue, 
      and serum total immunoglobulin E (IgE) and OVA-specific IgE, IgG1, and IgG2a were 
      analyzed and compared with negative and positive control groups. Cervical lymph 
      nodes (LNs) were harvested for flow cytometry analysis and cell proliferation 
      assay. RESULTS: In the treatment group, allergic symptom scores, eosinophil 
      infiltration, and mRNA levels of IL-4 and IL-13 were significantly lower in the 
      nasal tissue than in the positive control group. The IL-5 mRNA level, serum total 
      IgE, and OVA-specific IgE and IgG1 levels decreased in the treatment group; 
      however, the difference was not significant. In the cervical LNs, CD86 expression 
      had been down-regulated in CD11c(+)major histocompatibility complex II-high 
      (MHCII(high)) in the treatment group. Additionally, IL-4 secretion in the 
      lymphocyte culture from cervical LNs significantly decreased. CONCLUSIONS: The 
      results confirm the antiallergic effect of intranasal 1,25-dihydroxyvitamin D3. 
      It decreases CD 86 expression among CD11c(+)MHCII(high) cells and T-helper type 
      2-mediated inflammation in the cervical LNs. Therefore, topically applied 
      1,25-dihydroxyvitamin D3 can be a future therapeutic agent for allergic rhinitis.
CI  - Copyright (c) 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Cho, Sung Woo
AU  - Cho SW
AUID- ORCID: 0000-0003-0827-4471
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Bundang Hospital, Seoul National University College of Medicine, 
      Seongnam, Korea.
FAU - Zhang, Yu Lian
AU  - Zhang YL
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Bundang Hospital, Seoul National University College of Medicine, 
      Seongnam, Korea.
AD  - Center of Morphological Experiment, Medical College of Yanbian University, Yanji, 
      China.
FAU - Ko, Young Kyung
AU  - Ko YK
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Hospital, Seoul National University College of Medicine, Seoul, Korea.
FAU - Shin, Jae Min
AU  - Shin JM
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University 
      Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
FAU - Lee, Jun Ho
AU  - Lee JH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Hospital, Seoul National University College of Medicine, Seoul, Korea.
FAU - Rhee, Chae Seo
AU  - Rhee CS
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Bundang Hospital, Seoul National University College of Medicine, 
      Seongnam, Korea.
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Hospital, Seoul National University College of Medicine, Seoul, Korea.
FAU - Kim, Dong Young
AU  - Kim DY
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Hospital, Seoul National University College of Medicine, Seoul, Korea. 
      dongkim@snu.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6340801
OTO - NOTNLM
OT  - Animal model
OT  - allergic rhinitis
OT  - antiallergic agents
OT  - dendritic cell
OT  - intranasal administration
OT  - vitamin D
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2019/01/21 06:00
MHDA- 2019/01/21 06:01
PMCR- 2019/03/01
CRDT- 2019/01/21 06:00
PHST- 2018/05/22 00:00 [received]
PHST- 2018/09/24 00:00 [revised]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2019/01/21 06:00 [entrez]
PHST- 2019/01/21 06:00 [pubmed]
PHST- 2019/01/21 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 11.267 [pii]
AID - 10.4168/aair.2019.11.2.267 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2019 Mar;11(2):267-279. doi: 
      10.4168/aair.2019.11.2.267.