PMID- 30662203
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 0971-3026 (Print)
IS  - 1998-3808 (Electronic)
IS  - 0970-2016 (Linking)
VI  - 28
IP  - 4
DP  - 2018 Oct-Dec
TI  - Myocardial nulling pattern in cardiac amyloidosis on time of inversion scout 
      magnetic resonance imaging sequence - A new observation of temporal variability.
PG  - 427-432
LID - 10.4103/ijri.IJRI_84_18 [doi]
AB  - CONTEXT: The pattern of myocardial nulling in the inversion scout sequence [time 
      of inversion scout (TIS)] of cardiac magnetic resonance imaging (MRI) is an 
      accurate tool to detect cardiac amyloidosis. The pattern of nulling of myocardium 
      and blood at varying times post gadolinium injection and its relationship with 
      left ventricular mass (LVM) in amyloidosis have not been described previously. 
      AIMS: The aim is to study the nulling pattern of myocardium and blood at varying 
      times in TIS and assess its relationship with LVM and late gadolinium enhancement 
      (LGE) in amyloidosis. MATERIALS AND METHODS: This was a retrospective study of 
      109 patients with clinical suspicion of cardiac amyloidosis who underwent MRI. Of 
      these, 30 had MRI features of amyloidosis. The nulling pattern was assessed at 5 
      (TIS(5min)) and 10 (TIS(10min)) minutes (min) post contrast injection. Nulling 
      pattern was also assessed at 3min (TIS(3min)) in four patients and 7min 
      (TIS(7min)) in five patients. Myocardial mass index was calculated. Mann-Whitney 
      U test was done to assess statistical difference in the myocardial mass index 
      between patients with and without reversed nulling pattern (RNP) at TIS(5min). 
      RESULTS: RNP was observed in 58% at TIS(5min) and 89.6% at TIS(10min). Myocardial 
      mass index was significantly higher in patients with RNP at TIS(5min)[mean = 
      94.87 g/m(2); standard deviation (SD) =17.63) when compared with patients with 
      normal pattern (mean = 77.61 g/m(2); SD = 17.21) (U = 18; P = 0.0351). 
      CONCLUSION: In cardiac amyloidosis, TIS sequence shows temporal variability in 
      nulling pattern. Earlier onset of reverse nulling pattern shows a trend toward 
      more LVM and possibly more severe amyloid load.
FAU - Mahalingam, Harshavardhan
AU  - Mahalingam H
AD  - Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Chacko, Binita Riya
AU  - Chacko BR
AD  - Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Irodi, Aparna
AU  - Irodi A
AD  - Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Joseph, Elizabeth
AU  - Joseph E
AD  - Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Vimala, Leena R
AU  - Vimala LR
AD  - Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Thomson, Viji Samuel
AU  - Thomson VS
AD  - Department of Cardiology, Christian Medical College, Vellore, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Indian J Radiol Imaging
JT  - The Indian journal of radiology & imaging
JID - 8503873
PMC - PMC6319092
OTO - NOTNLM
OT  - Amyloidosis
OT  - TI scout
OT  - cardiac
OT  - magnetic resonance imaging
COIS- There are no conflicts of interest.
EDAT- 2019/01/22 06:00
MHDA- 2019/01/22 06:01
PMCR- 2018/10/01
CRDT- 2019/01/22 06:00
PHST- 2019/01/22 06:00 [entrez]
PHST- 2019/01/22 06:00 [pubmed]
PHST- 2019/01/22 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - IJRI-28-427 [pii]
AID - 10.4103/ijri.IJRI_84_18 [doi]
PST - ppublish
SO  - Indian J Radiol Imaging. 2018 Oct-Dec;28(4):427-432. doi: 
      10.4103/ijri.IJRI_84_18.