PMID- 30662396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 12
DP  - 2018
TI  - HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived 
      Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT 
      Pathway.
PG  - 498
LID - 10.3389/fncel.2018.00498 [doi]
LID - 498
AB  - Stem cell transplantation is a promising therapy for traumatic brain injury 
      (TBI), but low efficiency of survival and differentiation of transplanted stem 
      cells limits its clinical application. Histone deacetylase 1 (HDAC1) plays 
      important roles in self-renewal of stem cells as well as the recovery of brain 
      disorders. However, little is known about the effects of HDAC1 on the survival 
      and efficacy of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in 
      vivo. In this study, our results showed that HDAC1 silence promoted hUC-MSCs 
      engraftment in the hippocampus and increased the neuroprotective effects of 
      hUC-MSCs in TBI mouse model, which was accompanied by improved neurological 
      function, enhanced neurogenesis, decreased neural apoptosis, and reduced 
      oxidative stress in the hippocampus. Further mechanistic studies revealed that 
      the expressions of phosphorylated PTEN (p-PTEN), phosphorylated Akt (p-Akt), and 
      phosphorylated GSK-3beta (p-GSK-3beta) were upregulated. Intriguingly, the 
      neuroprotective effects of hUC-MSCs with HDAC1 silence on behavioral performance 
      of TBI mice was markedly attenuated by LY294002, an inhibitor of the PI3K/AKT 
      pathway. Taken together, our findings suggest that hUC-MSCs transplantation with 
      HDAC1 silence may provide a potential strategy for treating TBI in the future.
FAU - Xu, Ling
AU  - Xu L
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
AD  - Henan Provincial People's Hospital, Zhengzhou, China.
FAU - Xing, Qu
AU  - Xing Q
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Huang, Tuanjie
AU  - Huang T
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Zhou, Jiankang
AU  - Zhou J
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Liu, Tengfei
AU  - Liu T
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Cui, Yuanbo
AU  - Cui Y
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
AD  - Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou 
      University, Zhengzhou, China.
FAU - Cheng, Tian
AU  - Cheng T
AD  - The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
FAU - Wang, Yaping
AU  - Wang Y
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Zhou, Xinkui
AU  - Zhou X
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Yang, Bo
AU  - Yang B
AD  - The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
FAU - Yang, Greta Luyuan
AU  - Yang GL
AD  - Stuyvesant High School, New York, NY, United States.
FAU - Zhang, Jiewen
AU  - Zhang J
AD  - Henan Provincial People's Hospital, Zhengzhou, China.
FAU - Zang, Xingxing
AU  - Zang X
AD  - Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, 
      NY, United States.
FAU - Ma, Shanshan
AU  - Ma S
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Guan, Fangxia
AU  - Guan F
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
AD  - Henan Provincial People's Hospital, Zhengzhou, China.
AD  - The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20190104
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
EIN - Front Cell Neurosci. 2019 Sep 09;13:408. PMID: 31537983
PMC - PMC6328439
OTO - NOTNLM
OT  - PI3K/AKT
OT  - histone deacetylase 1
OT  - human umbilical cord derived mesenchymal stem cells
OT  - neuroprotection
OT  - traumatic brain injury
EDAT- 2019/01/22 06:00
MHDA- 2019/01/22 06:01
PMCR- 2018/01/01
CRDT- 2019/01/22 06:00
PHST- 2018/09/26 00:00 [received]
PHST- 2018/12/03 00:00 [accepted]
PHST- 2019/01/22 06:00 [entrez]
PHST- 2019/01/22 06:00 [pubmed]
PHST- 2019/01/22 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2018.00498 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2019 Jan 4;12:498. doi: 10.3389/fncel.2018.00498. 
      eCollection 2018.