PMID- 30663468
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 31
IP  - 1
DP  - 2020
TI  - Favorable effect of glycoprotein IIbIIIa inhibitors among STEMI patients treated 
      with primary PCI and incomplete ST resolution.
PG  - 48-54
LID - 10.1080/09537104.2018.1562171 [doi]
AB  - Incomplete ST resolution after primary percutaneous coronary interventions (pPCI) 
      in STEMI patients is a well known prognostic marker, associated with the 
      occurrence of microvascular obstruction and increased mortality. The effects of 
      the use of glycoprotein IIbIIIa inhibitors (GPIs) in this peculiar subset of 
      high- risk patients is still unknown. The aim of the present study was to assess 
      whether the GPIs administration would result in improved outcome in ST elevation 
      myocardial infarction (STEMI) patients with incomplete ST resolution (ISTR).All 
      consecutive STEMI patients who underwent pPCI at our hospital between 2005 and 
      2014 were enrolled (n = 2001). ST resolution was defined as incomplete with a 
      < 70% resolution of initial ST shift. Mortality analyses were performed by 
      Kaplan-Meier curves, multivariable analysis through Cox regressions and 
      propensity matching score. The incidence of ISTR was 29% (n = 592). Among ISTR 
      patients, GPIs use was an independent predictor of better prognosis (HR 0.39, 95% 
      CI 0.16-0.96, p < 0.04). Propensity matched analysis confirmed that the use of 
      GPIs was associated with a lower 30-day (6.1% vs 13.4%, p = 0.02) and 1-year 
      (8.4% vs 15.1%, p = 0.045) mortality. STEMI patients treated with pPCI and 
      presenting ISTR show a poor outcome. The use of GPIs in these patients is 
      associated with improved survival at 30 days and at 1 year; the causes for these 
      favorable effects remain speculative and could be related to the development and 
      evolution of microvascular obstruction.
FAU - Somaschini, Alberto
AU  - Somaschini A
AUID- ORCID: 0000-0003-1223-6128
AD  - Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, 
      Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
AD  - Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, 
      Italy.
FAU - Cornara, Stefano
AU  - Cornara S
AUID- ORCID: 0000-0002-4311-2139
AD  - Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, 
      Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
AD  - Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, 
      Italy.
FAU - Ferlini, Marco
AU  - Ferlini M
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Crimi, Gabriele
AU  - Crimi G
AUID- ORCID: 0000-0002-2852-061X
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Camporotondo, Rita
AU  - Camporotondo R
AD  - Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, 
      Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Gnecchi, Massimiliano
AU  - Gnecchi M
AD  - Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, 
      Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
AD  - Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, 
      Italy.
FAU - Ferrario Ormezzano, Maurizio
AU  - Ferrario Ormezzano M
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Oltrona Visconti, Luigi
AU  - Oltrona Visconti L
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - De Ferrari, Gaetano M
AU  - De Ferrari GM
AD  - Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, 
      Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
AD  - Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, 
      Italy.
FAU - De Servi, Stefano
AU  - De Servi S
AD  - Division of Cardiology, IRCCS Multimedica, Sesto San Giovanni (MI), Italy.
LA  - eng
PT  - Journal Article
DEP - 20190120
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - 0 (Biomarkers)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Comorbidity
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*adverse effects/methods
MH  - Platelet Aggregation Inhibitors/*pharmacology/therapeutic use
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors
MH  - ST Elevation Myocardial Infarction/*complications/diagnosis/therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - GPI
OT  - ST resolution
OT  - STEMI
EDAT- 2019/01/22 06:00
MHDA- 2020/04/21 06:00
CRDT- 2019/01/22 06:00
PHST- 2019/01/22 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/01/22 06:00 [entrez]
AID - 10.1080/09537104.2018.1562171 [doi]
PST - ppublish
SO  - Platelets. 2020;31(1):48-54. doi: 10.1080/09537104.2018.1562171. Epub 2019 Jan 
      20.