PMID- 30664447
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20190725
IS  - 1211-4286 (Print)
IS  - 1211-4286 (Linking)
VI  - 61
IP  - 4
DP  - 2018
TI  - Topiramate Reduces Aortic Cross-Clamping-Induced Lung Injury in Male Rats.
PG  - 144-149
LID - 10.14712/18059694.2018.133 [doi]
AB  - BACKGROUND: Topiramate (TPM) decreases cytokine release and generation of 
      reactive oxygen species (ROS). Cytokine and endothelin-1 (ET-1) secretion and ROS 
      formation play an important role in ischemia-reperfusion (I/R) injury. We aimed 
      to evaluate whether TPM prevents damage occurring in lung tissue during I/R. 
      MATERIALS AND METHODS: A total of 27 Wistar albino rats were divided into three 
      groups of nine. To the I/R group, two hours of ischemia via infrarenal abdominal 
      aorta cross-ligation and then two hours of reperfusion process were applied. TPM 
      (100 mg/kg/day) orally for seven days was administered in the TPM treatment 
      group. After the last dose of TPM treatment, respectively, two hours of ischemia 
      and two hours of reperfusion were applied in this group. RESULTS: Tumor necrosis 
      factor-alpha (TNF-alpha) (p < 0.05), malondialdehyde (MDA) (p < 0.05), 
      myeloperoxidase (MPO) (p < 0.05) and ET-1 (p < 0.05) levels of TPM treatment 
      group's lung tissue were significantly lower than for the I/R group. Caspase-3 
      and histopathological damage were rather lower than that of the I/R group. 
      CONCLUSIONS: During I/R, lung damage occurs due to excessive TNF-alpha and ET-1 
      release and ROS generation. TPM could well reduce development of lung damage by 
      decreasing cytokine and ET-1 release and levels of ROS produced.
FAU - Kurt, Aysel
AU  - Kurt A
AD  - Private Practice, Department of Thoracic Surgery, Rize, Turkey.
FAU - Kalkan, Yildiray
AU  - Kalkan Y
AD  - Private Practice, Department of Histology and Embryology, Rize, Turkey.
FAU - Turut, Hasan
AU  - Turut H
AD  - Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic 
      Surgery, Rize, Turkey.
FAU - Cure, Medine Cumhur
AU  - Cure MC
AD  - Istanbul Laboratory, Department of Biochemistry, Istanbul, Turkey.
FAU - Tumkaya, Levent
AU  - Tumkaya L
AD  - Recep Tayyip Erdogan University, School of Medicine, Department of Histology and 
      Embryology, Rize, Turkey.
FAU - Cure, Erkan
AU  - Cure E
AD  - Camlica Erdem Hospital, Department of Internal Medicine, Istanbul, Turkey. 
      erkancure@yahoo.com.
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Acta Medica (Hradec Kralove)
JT  - Acta medica (Hradec Kralove)
JID - 9705947
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0H73WJJ391 (Topiramate)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.22.- (Caspase 3)
MH  - Animals
MH  - Aorta, Abdominal
MH  - Biomarkers/blood
MH  - Caspase 3/blood
MH  - Ligation
MH  - Lung Injury/*drug therapy
MH  - Male
MH  - Malondialdehyde/blood
MH  - Peroxidase/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/*drug therapy
MH  - Topiramate/*pharmacology
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - endothelin-1
OT  - ischemia-reperfusion
OT  - lung injury
OT  - topiramate
OT  - tumor necrosis factor-alpha
EDAT- 2019/01/22 06:00
MHDA- 2019/07/26 06:00
CRDT- 2019/01/22 06:00
PHST- 2019/01/22 06:00 [entrez]
PHST- 2019/01/22 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
AID - am_2018061040144 [pii]
AID - 10.14712/18059694.2018.133 [doi]
PST - ppublish
SO  - Acta Medica (Hradec Kralove). 2018;61(4):144-149. doi: 
      10.14712/18059694.2018.133.