PMID- 30664560 OWN - NLM STAT- MEDLINE DCOM- 20200730 LR - 20211118 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 68 IP - 4 DP - 2019 Apr TI - Pediatric Endoscopy and High-risk Patients: A Clinical Report From the NASPGHAN Endoscopy Committee. PG - 595-606 LID - 10.1097/MPG.0000000000002277 [doi] AB - Pediatric gastrointestinal endoscopy has been established as safe and effective for diagnosis and management of many pediatric gastrointestinal diseases. Nevertheless, certain patient and procedure factors should be recognized that increase the risk of intra- and/or postprocedural adverse events (AEs). AEs associated with endoscopic procedures can broadly be categorized as involving sedation-related physiological changes, bleeding, perforation, and infection. Factors which may increase patient risk for such AEs include but are not limited to, cardiopulmonary diseases, anatomical airway or craniofacial abnormalities, compromised intestinal luminal wall integrity, coagulopathies, and compromised immune systems. Examples of high-risk patients include patients with congenital heart disease, craniofacial abnormalities, connective tissues diseases, inflammatory bowel disease, and children undergoing treatment for cancer. This clinical report is intended to help guide clinicians stratify patient risks and employ clinical practices that may minimize AEs during and after endoscopy. These include use of CO2 insufflation, endoscopic techniques for maneuvers such as biopsies, and endoscope loop-reduction to mitigate the risk of such complications such as bleeding and intestinal perforation. Endoscopic infection risk and guidance regarding periprocedural antibiotics are also discussed. FAU - Lightdale, Jenifer R AU - Lightdale JR AD - Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, UMass Memorial Children's Medical Center, University of Massachusetts, Westborough, MA. FAU - Liu, Quin Y AU - Liu QY AD - Cedars-Sinai Medical Center, Los Angeles, CA. FAU - Sahn, Benjamin AU - Sahn B AD - Cohen Children's Medical Center, Northwell Health; New Hyde Park, NY. FAU - Troendle, David M AU - Troendle DM AD - UT Southwestern Medical Center, Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Health - Children's Medical Center Dallas. FAU - Thomson, Mike AU - Thomson M AD - Department of Paediatric Gastroenterology, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, UK. FAU - Fishman, Douglas S AU - Fishman DS AD - Section of Pediatric Gastroenterology, Hepatology and Nutrition; Baylor College of Medicine, Texas Childrens Hospital; Houston, Texas. CN - NASPGHAN Endoscopy and Procedures Committee LA - eng GR - U01 DK108334/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Practice Guideline PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Child MH - Endoscopy, Gastrointestinal/*adverse effects MH - Female MH - Gastrointestinal Diseases/*diagnosis/pathology MH - Humans MH - Male MH - Postoperative Complications MH - Societies, Medical PMC - PMC8597353 MID - NIHMS1752919 COIS- The authors report no conflicts of interest. EDAT- 2019/01/22 06:00 MHDA- 2020/07/31 06:00 PMCR- 2021/11/17 CRDT- 2019/01/22 06:00 PHST- 2019/01/22 06:00 [pubmed] PHST- 2020/07/31 06:00 [medline] PHST- 2019/01/22 06:00 [entrez] PHST- 2021/11/17 00:00 [pmc-release] AID - 10.1097/MPG.0000000000002277 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):595-606. doi: 10.1097/MPG.0000000000002277.