PMID- 30666753
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 40
IP  - 8
DP  - 2019 Jun 1
TI  - Structural and functional asymmetry of medial temporal subregions in unilateral 
      temporal lobe epilepsy: A 7T MRI study.
PG  - 2390-2398
LID - 10.1002/hbm.24530 [doi]
AB  - Mesial temporal lobe epilepsy (TLE) is a common neurological disorder affecting 
      the hippocampus and surrounding medial temporal lobe (MTL). Although prior 
      studies have analyzed whole-brain network distortions in TLE patients, the 
      functional network architecture of the MTL at the subregion level has not been 
      examined. In this study, we utilized high-resolution 7T T2-weighted magnetic 
      resonance imaging (MRI) and resting-state BOLD-fMRI to characterize volumetric 
      asymmetry and functional network asymmetry of MTL subregions in unilateral 
      medically refractory TLE patients and healthy controls. We subdivided the TLE 
      group into mesial temporal sclerosis patients (TLE-MTS) and MRI-negative 
      nonlesional patients (TLE-NL). Using an automated multi-atlas segmentation 
      pipeline, we delineated 10 MTL subregions per hemisphere for each subject. We 
      found significantly different patterns of volumetric asymmetry between the two 
      groups, with TLE-MTS exhibiting volumetric asymmetry corresponding to decreased 
      volumes ipsilaterally in all hippocampal subfields, and TLE-NL exhibiting no 
      significant volumetric asymmetries other than a mild decrease in 
      whole-hippocampal volume ipsilaterally. We also found significantly different 
      patterns of functional network asymmetry in the CA1 subfield and whole 
      hippocampus, with TLE-NL patients exhibiting asymmetry corresponding to increased 
      connectivity ipsilaterally and TLE-MTS patients exhibiting asymmetry 
      corresponding to decreased connectivity ipsilaterally. Our findings provide 
      initial evidence that functional neuroimaging-based network properties within the 
      MTL can distinguish between TLE subtypes. High-resolution MRI has potential to 
      improve localization of underlying brain network disruptions in TLE patients who 
      are candidates for surgical resection.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Shah, Preya
AU  - Shah P
AUID- ORCID: 0000-0001-8360-6400
AD  - Department of Bioengineering, School of Engineering and Applied Science, 
      University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Center for Neuroengineering and Therapeutics, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Bassett, Danielle S
AU  - Bassett DS
AUID- ORCID: 0000-0002-6183-4493
AD  - Department of Bioengineering, School of Engineering and Applied Science, 
      University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Department of Electrical and Systems Engineering, School of Engineering and 
      Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Department of Physics and Astronomy, College of Arts and Sciences, University of 
      Pennsylvania, Philadelphia, Pennsylvania.
FAU - Wisse, Laura E M
AU  - Wisse LEM
AD  - Penn Image Computing and Science Laboratory, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Detre, John A
AU  - Detre JA
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Stein, Joel M
AU  - Stein JM
AD  - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Yushkevich, Paul A
AU  - Yushkevich PA
AD  - Penn Image Computing and Science Laboratory, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Shinohara, Russell T
AU  - Shinohara RT
AD  - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Elliott, Mark A
AU  - Elliott MA
AD  - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Das, Sandhitsu R
AU  - Das SR
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Penn Image Computing and Science Laboratory, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Davis, Kathryn A
AU  - Davis KA
AUID- ORCID: 0000-0002-7020-6480
AD  - Center for Neuroengineering and Therapeutics, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
LA  - eng
GR  - K23-NS073801-01/NH/NIH HHS/United States
GR  - R01 NS099348/NS/NINDS NIH HHS/United States
GR  - Mirowski Family Foundation/International
GR  - R03 EB016923/EB/NIBIB NIH HHS/United States
GR  - 1R01NS099348-02/NH/NIH HHS/United States
GR  - T32-EB009384/NH/NIH HHS/United States
GR  - R01 NS085211/NS/NINDS NIH HHS/United States
GR  - Center for Biomedical Image Computing and Analytics Seed Award/International
GR  - R01MH112847/NH/NIH HHS/United States
GR  - UL1TR001878/TAPITMAT-TBIC/International
GR  - R01 MH112847/MH/NIMH NIH HHS/United States
GR  - R01NS085211/NH/NIH HHS/United States
GR  - UL1 TR001878/TR/NCATS NIH HHS/United States
GR  - K23 NS092973/NS/NINDS NIH HHS/United States
GR  - R03-EB16923-01A1/NH/NIH HHS/United States
GR  - R01 EB017255/EB/NIBIB NIH HHS/United States
GR  - UL1TR001878/Transdisciplinary Awards Program in Translational Medicine and 
      Therapeutics-Translational Biomedical Imaging Core (TAPITMAT-TBIC)/International
GR  - R01EB017255/NH/NIH HHS/United States
GR  - Thornton Foundation/International
GR  - T32 EB009384/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190121
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - CA1 Region, Hippocampal/diagnostic imaging/pathology/physiopathology
MH  - *Epilepsy, Temporal Lobe/diagnostic imaging/pathology/physiopathology
MH  - Female
MH  - *Functional Laterality/physiology
MH  - Functional Neuroimaging/*methods
MH  - *Hippocampus/diagnostic imaging/pathology/physiopathology
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Nerve Net/diagnostic imaging/pathology/physiopathology
MH  - Sclerosis/pathology
MH  - *Temporal Lobe/diagnostic imaging/pathology/physiopathology
PMC - PMC6497534
MID - NIHMS1011643
OTO - NOTNLM
OT  - 7 tesla MRI
OT  - medial temporal lobe
OT  - mesial temporal sclerosis
OT  - network neuroscience
OT  - resting-state fMRI
OT  - temporal lobe epilepsy
EDAT- 2019/01/23 06:00
MHDA- 2020/04/14 06:00
PMCR- 2019/01/21
CRDT- 2019/01/23 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/01/11 00:00 [accepted]
PHST- 2019/01/23 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/01/23 06:00 [entrez]
PHST- 2019/01/21 00:00 [pmc-release]
AID - HBM24530 [pii]
AID - 10.1002/hbm.24530 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2019 Jun 1;40(8):2390-2398. doi: 10.1002/hbm.24530. Epub 2019 Jan 
      21.