PMID- 30666824
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 22
IP  - 4
DP  - 2019 Apr
TI  - Disease activity and functional status associated with health-related quality of 
      life and patient-acceptable symptom state in patients with psoriatic arthritis in 
      Thailand: A cross-sectional study.
PG  - 700-707
LID - 10.1111/1756-185X.13473 [doi]
AB  - AIM: To identify factors associated with the EuroQol-5 Dimensions-5 levels 
      (EQ-5D-5L) and patient acceptable symptom state (PASS) and to estimate health 
      utility (HU) in Thai patients with psoriatic arthritis (PsA). METHODS: A 
      cross-sectional study of consecutive PsA patients visiting Siriraj Hospital was 
      performed between 31 May, 2012 and 31 March, 2016. Data of patient demographics, 
      HU outcomes (Thai EQ-5D-5L), disease activity (Disease Activity Index for 
      Psoriatic Arthritis [DAPSA], the Clinical DAPSA [cDAPSA], the minimal disease 
      activity [MDA]), and the Health Assessment Questionnaire (HAQ) were collected. 
      Regression analyses were used to explore factors associated with each EQ-5D 
      domain, HU, and PASS. RESULTS: Of 129 PsA patients, the mean age was 47.6 years; 
      53.5% were male. The mean HU was 0.76. Univariable analysis showed lower disease 
      activity and less impaired function were significantly associated with higher HU 
      and no to mild problem in each EQ-5D domain. Multivariable analysis showed HAQ 
      and disease activity indices (cDAPSA, DAPSA, MDA) adjusting for age, had good 
      goodness-of-fit to HU (adjusted R(2) : 0.63-0.65). Patients answering "yes" to 
      PASS had significantly longer disease duration of PsA, higher HU, lower disease 
      activity, less disability, and were more often married than those answering "no" 
      to PASS. Pain problem was the most important association to PASS adjusting for 
      other domains and age. CONCLUSIONS: Disease activity and functional status in PsA 
      patients were significant factors related to HU and PASS. To improve quality of 
      life, the goal of treatment should be achieving remission, improving function, 
      and controlling pain.
CI  - (c) 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Chiowchanwisawakit, Praveena
AU  - Chiowchanwisawakit P
AUID- ORCID: 0000-0002-4253-9229
AD  - Division of Rheumatology, Department of Medicine, Faculty of Medicine, Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
FAU - Srinonprasert, Varalak
AU  - Srinonprasert V
AD  - Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, 
      Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Thaweeratthakul, Phakhamon
AU  - Thaweeratthakul P
AD  - Division of Rheumatology, Department of Medicine, Faculty of Medicine, Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
FAU - Katchamart, Wanruchada
AU  - Katchamart W
AD  - Division of Rheumatology, Department of Medicine, Faculty of Medicine, Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
LA  - eng
GR  - R015533011/Siriraj Research Fund, Faculty of Medicine Siriraj Hospital, Mahidol 
      University/
PT  - Journal Article
DEP - 20190121
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
SB  - IM
MH  - Arthritis, Psoriatic/diagnosis/drug therapy/physiopathology/*psychology
MH  - *Cost of Illness
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/diagnosis/drug therapy/physiopathology/*psychology
MH  - Patient Reported Outcome Measures
MH  - Prognosis
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Thailand
OTO - NOTNLM
OT  - EQ-5D-5L
OT  - MDA
OT  - PASS
OT  - cDAPSA
OT  - psoriatic arthritis
EDAT- 2019/01/23 06:00
MHDA- 2019/09/04 06:00
CRDT- 2019/01/23 06:00
PHST- 2018/08/04 00:00 [received]
PHST- 2018/12/19 00:00 [revised]
PHST- 2018/12/22 00:00 [accepted]
PHST- 2019/01/23 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/01/23 06:00 [entrez]
AID - 10.1111/1756-185X.13473 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2019 Apr;22(4):700-707. doi: 10.1111/1756-185X.13473. Epub 2019 
      Jan 21.