PMID- 30667082
OWN - NLM
STAT- MEDLINE
DCOM- 20200417
LR  - 20200417
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 38
IP  - 4
DP  - 2019 Apr
TI  - Model-based exploration of the variability in lake trout (Salvelinus namaycush) 
      bioaccumulation factors: The influence of physiology and trophic relationships.
PG  - 831-840
LID - 10.1002/etc.4368 [doi]
AB  - Because dietary consumption of fish is often a major vector of human exposure to 
      persistent organic pollutants (POPs), much effort is directed toward a 
      quantitative understanding of fish bioaccumulation using mechanistic models. 
      However, many such models fail to explicitly consider how uptake and loss rate 
      constants relate to fish physiology. We calculated the bioaccumulation factors 
      (BAFs) of hypothetical POPs, with octanol-water partition coefficients ranging 
      from 10(4.5) to 10(8.5) , in lake trout (Salvelinus namaycush) with a food-web 
      bioaccumulation model that uses bioenergetics to ensure that physiological 
      parameters applied to a species are internally consistent. We modeled fish in 6 
      Canadian lakes (Great Slave Lake, Lake Ontario, Source Lake, Happy Isle Lake, 
      Lake Opeongo, and Lake Memphremagog) to identify the factors that cause the BAFs 
      of differently sized lake trout to vary between and within lakes. When comparing 
      differently sized lake trout within a lake, larger fish tend to have the highest 
      BAF because they allocate less energy toward growth than smaller fish and have 
      higher activity levels. When comparing fish from different lakes, the model finds 
      that diet composition and prey energy density become important in determining the 
      BAF, in addition to activity and the amount of total energy allocated to growth. 
      Environ Toxicol Chem 2019;38:831-840. (c) 2019 SETAC.
CI  - (c) 2019 SETAC.
FAU - Baskaran, Sivani
AU  - Baskaran S
AD  - Department of Chemistry, University of Toronto Scarborough, Toronto, Ontario, 
      Canada.
FAU - Armitage, James M
AU  - Armitage JM
AD  - Department of Physical and Environmental Science, University of Toronto 
      Scarborough, Toronto, Ontario, Canada.
FAU - Wania, Frank
AU  - Wania F
AD  - Department of Chemistry, University of Toronto Scarborough, Toronto, Ontario, 
      Canada.
AD  - Department of Physical and Environmental Science, University of Toronto 
      Scarborough, Toronto, Ontario, Canada.
LA  - eng
GR  - Natural Sciences and Engineering Research Council of Canada/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190307
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - *Bioaccumulation
MH  - Food Chain
MH  - Humans
MH  - Lakes/*chemistry
MH  - *Models, Biological
MH  - Ontario
MH  - Trout/growth & development/*metabolism
MH  - Water Pollutants, Chemical/analysis/*metabolism
OTO - NOTNLM
OT  - Bioaccumulation
OT  - Bioenergetics
OT  - Fish growth
OT  - Fish size
OT  - Lake trout
OT  - Model
EDAT- 2019/01/23 06:00
MHDA- 2020/04/18 06:00
CRDT- 2019/01/23 06:00
PHST- 2018/08/22 00:00 [received]
PHST- 2018/12/06 00:00 [revised]
PHST- 2019/01/16 00:00 [accepted]
PHST- 2019/01/23 06:00 [pubmed]
PHST- 2020/04/18 06:00 [medline]
PHST- 2019/01/23 06:00 [entrez]
AID - 10.1002/etc.4368 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2019 Apr;38(4):831-840. doi: 10.1002/etc.4368. Epub 2019 
      Mar 7.