PMID- 30667530
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 74
IP  - 6
DP  - 2019 Jun
TI  - Safety and reproducibility of nasal allergen challenge.
PG  - 1125-1134
LID - 10.1111/all.13728 [doi]
AB  - BACKGROUND: The nasal allergen challenge (NAC) is a useful tool for the diagnosis 
      of allergic rhinitis (AR) and local allergic rhinitis (LAR) and might serve to 
      design and monitor allergen immunotherapy. Nevertheless, data about its safety 
      and reproducibility are scarce. OBJECTIVE: To investigate the safety and 
      reproducibility of NAC in pediatric and adult rhinitis patients with/without 
      asthmatic symptoms, and in healthy controls. METHODS: A retrospective evaluation 
      of the NACs conducted in our Unit for 2005-2017 and monitored by acoustic 
      rhinometry and nasal-ocular symptoms was performed to analyze the safety of two 
      methods for allergen application (metered spray & micropipette) and NAC protocols 
      (NAC with single or multiple allergens/session [NAC-S & NAC-M]). The adverse 
      events (AEs), spirometry values, and rescue medication required for AE were 
      recorded. The reproducibility was examined by a prospective analysis of three 
      repeated NAC-S performed at 1-2-month interval in AR, LAR and nonallergic 
      rhinitis patients, and in healthy controls. RESULTS: A total of 11 499 NACs were 
      performed in 518 children and 5830 adults. Only four local AE occurred, and 
      99.97% of NACs were well tolerated. The reproducibility and positive and negative 
      predictive values of three consecutive NAC-S performed in 710 subjects were 
      97.32%, 100%, and 92.91%, respectively. There were no false-positive results in 
      the 710 analyzed subjects. Safety and reproducibility were comparable between the 
      methods of allergen application and the rhinitis phenotypes. CONCLUSION: The NAC 
      is a safe and highly reproducible diagnostic test ready to be used in the 
      clinical practice in both children and adults with or without asthma.
CI  - (c) 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Eguiluz-Gracia, Ibon
AU  - Eguiluz-Gracia I
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
FAU - Testera-Montes, Almudena
AU  - Testera-Montes A
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
FAU - Gonzalez, Miguel
AU  - Gonzalez M
AUID- ORCID: 0000-0001-8912-6619
AD  - Research Laboratory-Allergy Unit, IBIMA-Hospital Regional Universitario de 
      Malaga-ARADyAL, UMA, Malaga, Spain.
FAU - Perez-Sanchez, Natalia
AU  - Perez-Sanchez N
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
FAU - Ariza, Adriana
AU  - Ariza A
AD  - Research Laboratory-Allergy Unit, IBIMA-Hospital Regional Universitario de 
      Malaga-ARADyAL, UMA, Malaga, Spain.
FAU - Salas, Maria
AU  - Salas M
AUID- ORCID: 0000-0002-0583-9492
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
FAU - Moreno-Aguilar, Carmen
AU  - Moreno-Aguilar C
AD  - Immunology and Allergy Unit, IMIBIC-Hospital Regional Universitario Reina 
      Sofia-ARADyAL, Cordoba, Spain.
FAU - Campo, Paloma
AU  - Campo P
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
FAU - Torres, Maria Jose
AU  - Torres MJ
AUID- ORCID: 0000-0001-5228-471X
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
FAU - Rondon, Carmen
AU  - Rondon C
AUID- ORCID: 0000-0003-0976-3402
AD  - Allergy Unit, IBIMA-Hospital Regional Universitario de Malaga-ARADyAL, UMA, 
      Malaga, Spain.
LA  - eng
GR  - ARADyAL RD 16/00006/0018/Instituto de Salud Carlos III/International
GR  - ARADyAL RD16/0006/000/Instituto de Salud Carlos III/International
GR  - CD17/0146/Instituto de Salud Carlos III/International
GR  - CM17/00140/Instituto de Salud Carlos III/International
GR  - CM17/00141/Instituto de Salud Carlos III/International
GR  - FIS PI12/00900/Instituto de Salud Carlos III/International
GR  - FIS PI14/0864/Instituto de Salud Carlos III/International
GR  - FIS PI17/01410/Instituto de Salud Carlos III/International
GR  - RiRAAF RD07/0064/Instituto de Salud Carlos III/International
GR  - ARADyAL RD 16/00006/0018/European Regional Development Fund/International
GR  - ARADyAL RD16/0006/000/European Regional Development Fund/International
GR  - RiRAAF RD07/0064/European Regional Development Fund/International
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190220
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/administration & dosage/*immunology
MH  - Asthma/diagnosis
MH  - Bronchial Spasm/etiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Provocation Tests/*adverse effects/*methods
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/*diagnosis
MH  - Rhinometry, Acoustic
MH  - Young Adult
OTO - NOTNLM
OT  - local allergic rhinitis
OT  - nasal allergen challenge
OT  - reproducibility
OT  - safety
EDAT- 2019/01/23 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/01/23 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2018/12/19 00:00 [revised]
PHST- 2018/12/27 00:00 [accepted]
PHST- 2019/01/23 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/01/23 06:00 [entrez]
AID - 10.1111/all.13728 [doi]
PST - ppublish
SO  - Allergy. 2019 Jun;74(6):1125-1134. doi: 10.1111/all.13728. Epub 2019 Feb 20.