PMID- 30668176
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1549-7798 (Electronic)
IS  - 1040-9238 (Linking)
VI  - 53
IP  - 6
DP  - 2018 Dec
TI  - Molecular intricacies of aerobic glycolysis in cancer: current insights into the 
      classic metabolic phenotype.
PG  - 667-682
LID - 10.1080/10409238.2018.1556578 [doi]
AB  - Aerobic glycolysis is the process of oxidation of glucose into pyruvate followed 
      by lactate production under normoxic condition. Distinctive from its anaerobic 
      counterpart (i.e. glycolysis that occurs under hypoxia), aerobic glycolysis is 
      frequently witnessed in cancers, popularly known as the "Warburg effect", and it 
      is one of the earliest known evidences of metabolic alteration in neoplasms. 
      Intracellularly, aerobic glycolysis circumvents mitochondrial oxidative 
      phosphorylation (OxPhos), facilitating an increased rate of glucose hydrolysis. 
      This in turn enables cancer cells to successfully compete with normal cells for 
      glucose uptake in order to maintain uninterrupted growth. In addition, evading 
      OxPhos mitigates excessive generation/accumulation of reactive oxygen species 
      that otherwise may be deleterious to cells. Emerging data indicate that aerobic 
      glycolysis in cancer also promotes glutaminolysis to satisfy the precursor 
      requirements of certain biosynthetic processes (e.g. nucleic acids). Next, the 
      metabolic intermediates of aerobic glycolysis also feed the pentose phosphate 
      pathway (PPP) to facilitate macromolecular biosynthesis necessary for cancer cell 
      growth and proliferation. Extracellularly, the extrusion of the end-product of 
      aerobic glycolysis, i.e. lactate, alters the tumor microenvironment, and impacts 
      cancer-associated cells. Collectively, accumulating data unequivocally 
      demonstrate that aerobic glycolysis implicates myriad of molecular and functional 
      processes to support cancer progression. This review, in the light of recent 
      research, dissects the molecular intricacies of its regulation, and also 
      deliberates the emerging paradigms to target aerobic glycolysis in cancer 
      therapy.
FAU - Ganapathy-Kanniappan, Shanmugasundaram
AU  - Ganapathy-Kanniappan S
AUID- ORCID: 0000-0001-7176-3804
AD  - a The Division of Interventional Radiology, Russell H. Morgan Department of 
      Radiology & Radiological Science , The Johns Hopkins University School of 
      Medicine , Baltimore , MD , USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190122
PL  - England
TA  - Crit Rev Biochem Mol Biol
JT  - Critical reviews in biochemistry and molecular biology
JID - 8903774
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aerobiosis
MH  - Animals
MH  - *Cell Proliferation
MH  - Glucose/*metabolism
MH  - *Glycolysis
MH  - Humans
MH  - Neoplasms/*metabolism/pathology
MH  - *Oxidative Phosphorylation
MH  - *Pentose Phosphate Pathway
OTO - NOTNLM
OT  - Aerobic glycolysis
OT  - Warburg effect
OT  - lactate pH
OT  - mitochondrial OxPhos
OT  - monocarboxylate transporters
OT  - tumor metabolism
EDAT- 2019/01/23 06:00
MHDA- 2019/05/06 06:00
CRDT- 2019/01/23 06:00
PHST- 2019/01/23 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2019/01/23 06:00 [entrez]
AID - 10.1080/10409238.2018.1556578 [doi]
PST - ppublish
SO  - Crit Rev Biochem Mol Biol. 2018 Dec;53(6):667-682. doi: 
      10.1080/10409238.2018.1556578. Epub 2019 Jan 22.