PMID- 30668185
OWN - NLM
STAT- MEDLINE
DCOM- 20191203
LR  - 20191217
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 30
IP  - 8
DP  - 2019 Dec
TI  - Topical ketoconazole: a systematic review of current dermatological applications 
      and future developments.
PG  - 760-771
LID - 10.1080/09546634.2019.1573309 [doi]
AB  - Introduction: Although labeling changes and market withdrawal have been 
      implemented for oral ketoconazole (KTZ) due to serious adverse effects (AEs), 
      topical KTZ is generally thought to be effective and safe for the treatment of 
      superficial fungal infections. New dermatologic indications for the use of 
      topical KTZ have arisen such as onychomycosis, blepharitis, and hair loss. This 
      article aims to review the literature on topical KTZ's efficacy and AEs, as well 
      as provide an overview on current insights regarding its mechanism of action and 
      upcoming developments. Methods: A PubMed search was done to include randomized 
      controlled trials (RCTs) focusing on the use of topical KTZ in human subjects. 
      Results: Forty studies with 4566 patients were included in this review. Topical 
      KTZ is clinically effective for the treatment of Malassezia-related conditions 
      such as seborrheic dermatitis (SD) and pityriasis versicolor (PV) with a reported 
      efficacy of 63-90% and 71-89%, respectively. Conclusions: Topical KTZ 
      demonstrates high clinical efficacy for Malassezia-related conditions. More 
      efficacious alternatives are now available for Tinea and Candida. Although 
      topical KTZ is safe, clinicians should be aware that allergic contact dermatitis 
      may occur. Further studies should be completed to investigate the use of topical 
      KTZ for hair loss and inflammatory dermatoses.
FAU - Choi, Franchesca D
AU  - Choi FD
AD  - Department of Dermatology, University of California , Irvine , CA, USA.
AD  - College of Medicine, Kaohsiung Medical University , Kaohsiung , Taiwan.
FAU - Juhasz, Margit L W
AU  - Juhasz MLW
AD  - Department of Dermatology, University of California , Irvine , CA, USA.
FAU - Atanaskova Mesinkovska, Natasha
AU  - Atanaskova Mesinkovska N
AUID- ORCID: 0000-0002-2705-7002
AD  - Department of Dermatology, University of California , Irvine , CA, USA.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20190214
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Antifungal Agents)
RN  - R9400W927I (Ketoconazole)
SB  - IM
MH  - Administration, Topical
MH  - Alopecia/diagnosis/etiology
MH  - Antifungal Agents/adverse effects/*therapeutic use
MH  - Dermatitis, Seborrheic/*drug therapy
MH  - Humans
MH  - Ketoconazole/adverse effects/*therapeutic use
MH  - Malassezia/physiology
MH  - Randomized Controlled Trials as Topic
MH  - Tinea Versicolor/*drug therapy/microbiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Topical ketoconazole
OT  - androgenetic alopecia
OT  - pityriasis versicolor
OT  - seborrheic dermatitis
EDAT- 2019/01/23 06:00
MHDA- 2019/12/04 06:00
CRDT- 2019/01/23 06:00
PHST- 2019/01/23 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2019/01/23 06:00 [entrez]
AID - 10.1080/09546634.2019.1573309 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2019 Dec;30(8):760-771. doi: 10.1080/09546634.2019.1573309. 
      Epub 2019 Feb 14.