PMID- 30669738
OWN - NLM
STAT- MEDLINE
DCOM- 20190227
LR  - 20221207
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 40
IP  - 1
DP  - 2019 Jan 10
TI  - [Human leukocyte antigen polymorphism of HIV infected persons without disease 
      progress for long-term in Henan province, 2011-2016].
PG  - 89-92
LID - 10.3760/cma.j.issn.0254-6450.2019.01.018 [doi]
AB  - Objective: To understand the disease progression and human leukocyte antigen 
      (HLA) gene polymorphism of HIV-infected persons without disease progress for long 
      term, also known as long-term non-progressors (LTNPs), in Henan province. 
      Methods: A retrospective study was conducted in 48 LTNPs with complete detection 
      and follow-up information during 2011-2016 in Henan. Changes of CD(4)(+)T cells 
      counts (CD(4)) and viral load (VL) during follow-up period were discussed. 
      Polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) was 
      used for the analyses of HLA-A, HLA-B and HLA-DRB1 alleles between LTNPs and 
      healthy controls. Results: From 2011 to 2016, forty-eight LTNPs showed a decrease 
      of the quartile (P(25)-P(75)) of CD(4) from 601.00 (488.50-708.72)/mul to 494.00 
      (367.00-672.00)/mul, and the difference was significant (P<0.05). The increase of 
      the quartile (P(25)-P(75)) of log(10)VL from 3.40 (2.87-3.97) to 3.48 
      (2.60-4.37), but the difference was not significant (P>0.05). HLA polymorphism 
      analysis revealed that HLA-B*13:02 and HLA-B*40:06 were more common in LTNPs 
      (P<0.05), while HLA-B*46:01 and HLA-DRB1*09:01 were more common in healthy 
      controls (P<0.05). Conclusions: The CD(4) of LTNPs in Henan showed a downward 
      trend year by year. HLA-B*13:02 and B*40:06 might be associated with delayed 
      disease progression for HIV infected persons in Henan.
FAU - Xue, X J
AU  - Xue XJ
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
FAU - Yan, J Z
AU  - Yan JZ
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
FAU - Cheng, D
AU  - Cheng D
AD  - Xinxiang Prefecture Center for Disease Control and Prevention, Xinxiang 453000, 
      China.
FAU - Liu, C H
AU  - Liu CH
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
FAU - Liu, J
AU  - Liu J
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
FAU - Liu, Z
AU  - Liu Z
AD  - Henan Red Cross Blood Center, Zhengzhou 450016, China.
FAU - Tian, S A
AU  - Tian SA
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
FAU - Sun, D Y
AU  - Sun DY
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
FAU - Zhang, B W
AU  - Zhang BW
AD  - Henan Red Cross Blood Center, Zhengzhou 450016, China.
FAU - Wang, Z
AU  - Wang Z
AD  - Department of AIDS/STD Control and Prevention, Henan Provincial Center for 
      Disease Control and Prevention, Zhengzhou 450016, China.
LA  - chi
GR  - 162300410123/Henan Province Basic and Frontier Technology Research Project/
GR  - 201602311/Henan Medical Science and Technology Research Program/
GR  - 2018ZX10715009-003-002, 2017ZX10201101-001-010/National Science and Technology 
      Major Project/
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Disease Progression
MH  - Female
MH  - HIV
MH  - HIV Infections/*genetics/*immunology/virology
MH  - HIV-1/genetics/*immunology
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Retrospective Studies
MH  - Viral Load
OTO - NOTNLM
OT  - Genetic polymorphism
OT  - HIV
OT  - Human leukocyte antigen
OT  - Long-term non-progressor
EDAT- 2019/01/24 06:00
MHDA- 2019/02/28 06:00
CRDT- 2019/01/24 06:00
PHST- 2019/01/24 06:00 [entrez]
PHST- 2019/01/24 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
AID - 10.3760/cma.j.issn.0254-6450.2019.01.018 [doi]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Jan 10;40(1):89-92. doi: 
      10.3760/cma.j.issn.0254-6450.2019.01.018.