PMID- 30670903
OWN - NLM
STAT- MEDLINE
DCOM- 20190411
LR  - 20200225
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 83
IP  - 1
DP  - 2019 Jan
TI  - Comparison of 4 commercial modified-live porcine reproductive and respiratory 
      syndrome virus (PRRSV) vaccines against heterologous Korean PRRSV-1 and PRRSV-2 
      challenge.
PG  - 57-67
AB  - The efficacy of 4 commercial porcine reproductive and respiratory syndrome virus 
      (PRRSV) modified-live vaccines (MLV), against PRRSV-1 and PRRSV-2 was evaluated 
      and compared in growing pigs. Two of the vaccines were based on PRRSV-1 and two 
      on PRRSV-2. There were no significant differences between each of the two PRRSV-1 
      MLV vaccines and the two PRRSV-2 MLV vaccines respectively based on virology, 
      immunological, and pathological evaluations. Vaccination with either of the 
      PRRSV-1 MLV vaccines resulted in reduced PRRSV-1 but not PRRSV-2 viremia. 
      Additionally, vaccination with either of the PRRSV-1 MLV vaccines resulted in 
      reduction of lung lesions and PRRSV-1 positive cells in PRRSV-1 challenged pigs 
      but had no significant effect in PRRSV-2 challenged pigs. In contrast, 
      vaccination with either of the two PRRSV-2 MLV vaccines resulted in the reduction 
      of both PRRSV-1 and PRRSV-2 viremia. The PRRSV-2 MLV vaccines were also able to 
      effectively reduce lung lesions and PRRSV positive cells after challenge with 
      either PRRSV-1 or PRRSV-2. Our data suggest that while vaccination with PRRSV-1 
      MLV vaccines can be effective against PRRSV-1, only PRRSV-2 MLV vaccines can 
      protect against both Korean PRRSV-1 and PRRSV-2 challenges in this study.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Kim, Hanjin
AU  - Kim H
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Kim, Seeun
AU  - Kim S
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
LA  - eng
PT  - Clinical Trial, Veterinary
PT  - Journal Article
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Interferon-gamma
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*classification/immunology
MH  - RNA, Viral/blood
MH  - Random Allocation
MH  - Republic of Korea/epidemiology
MH  - Swine
MH  - Viral Vaccines/*immunology
MH  - Viremia
PMC - PMC6318830
EDAT- 2019/01/24 06:00
MHDA- 2019/04/12 06:00
PMCR- 2019/07/01
CRDT- 2019/01/24 06:00
PHST- 2018/01/25 00:00 [received]
PHST- 2018/04/16 00:00 [accepted]
PHST- 2019/01/24 06:00 [entrez]
PHST- 2019/01/24 06:00 [pubmed]
PHST- 2019/04/12 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - cjvr_01_57 [pii]
PST - ppublish
SO  - Can J Vet Res. 2019 Jan;83(1):57-67.