PMID- 30672022
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20201019
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 48
IP  - 3
DP  - 2019 Mar
TI  - Assessment of Interleukin-18 gene polymorphism and serum levels in oral lichen 
      planus in an Indian population.
PG  - 244-250
LID - 10.1111/jop.12830 [doi]
AB  - BACKGROUND: Oral lichen planus (OLP) is a chronic, inflammatory disease with 
      uncertain etiology. The aim of this study was to assess Interleukin-18 (IL-18) 
      gene polymorphism and serum levels in OLP cases of Indian origin and to compare 
      them with a control population of similar background. METHODS: The assessment of 
      single-nucleotide polymorphisms (SNPs) of IL-18 gene at promoter regions 
      -137(G/C) and -607(C/A) was done in 70 OLP cases and 70 healthy controls using 
      sequence-specific primer-polymerase chain reaction (SSP-PCR). In a subset of this 
      cohort, comprising of 41 OLP cases and 41 controls, serum IL-18 levels were 
      assessed using enzyme-linked immunosorbent assay (ELISA). RESULTS: Mean serum 
      levels of IL-18 among OLP cases were significantly higher when compared to 
      controls. Genotypic and allelic frequencies of IL-18 at position -137(G/C) showed 
      that GG genotype and allele G was significantly higher in OLP cases, whereas, GC 
      genotype and C allele was high in the control group. Polymorphism of IL-18 at 
      position -607(C/A) showed no significant differences. CONCLUSIONS: Gene 
      polymorphism at -137GG genotype and allele G seems to be associated with genetic 
      susceptibility to OLP whereas -137GC and allele C may have a protective role 
      against its development. However, our study lacks clear statistical correlation, 
      the differences observed could be caused by sampling problems and the results 
      could not be fully representative of Indian patients with OLP. Further studies 
      are warranted to explore the role of IL-18 genetic polymorphisms in OLP 
      development.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Negi, Deepika
AU  - Negi D
AD  - Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental 
      Sciences, New Delhi, India.
FAU - Urs, Aadithya B
AU  - Urs AB
AUID- ORCID: 0000-0002-1299-5805
AD  - Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental 
      Sciences, New Delhi, India.
FAU - Kumar, Priya
AU  - Kumar P
AD  - Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental 
      Sciences, New Delhi, India.
FAU - Mahajan, Bhawna
AU  - Mahajan B
AD  - Department of Biochemistry, Govind Ballabh Pant Institute of Post Graduate 
      Medical Education and Research, New Delhi, India.
FAU - Singh, Hanspal
AU  - Singh H
AD  - Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental 
      Sciences, New Delhi, India.
FAU - Polipalli, Sunil K
AU  - Polipalli SK
AD  - Pediatrics Research and Genetics Laboratory, Department of Pediatrics, Maulana 
      Azad Medical College, New Delhi, India.
FAU - Kapoor, Seema
AU  - Kapoor S
AD  - Pediatrics Research and Genetics Laboratory, Department of Pediatrics, Maulana 
      Azad Medical College, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20190207
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Biomarkers)
RN  - 0 (Genetic Markers)
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Association Studies
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - India
MH  - Interleukin-18/*blood/*genetics
MH  - Lichen Planus, Oral/*diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - gene polymorphism
OT  - interleukin-18
OT  - oral lichen planus
EDAT- 2019/01/24 06:00
MHDA- 2019/07/10 06:00
CRDT- 2019/01/24 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/12/07 00:00 [revised]
PHST- 2019/01/07 00:00 [accepted]
PHST- 2019/01/24 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2019/01/24 06:00 [entrez]
AID - 10.1111/jop.12830 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2019 Mar;48(3):244-250. doi: 10.1111/jop.12830. Epub 2019 Feb 
      7.